Growth hormone reduces inflammation in postmenopausal women with abdominal obesity: a 12-month, randomized, placebo-controlled trial.

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Franco Ramos, Celina,1956Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine (författare)

Growth hormone reduces inflammation in postmenopausal women with abdominal obesity: a 12-month, randomized, placebo-controlled trial.

Artikel/kapitelEngelska2007

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The Endocrine Society,2007

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LIBRIS-ID:oai:gup.ub.gu.se/60279
https://gup.ub.gu.se/publication/60279URI
https://doi.org/10.1210/jc.2007-0068DOI

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Språk:engelska

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CONTEXT: Abdominal obesity is associated with low GH secretion, elevated circulating markers of inflammation, and increased risk of cardiovascular disease. OBJECTIVE: The objective was to study the effect of GH treatment on inflammatory markers and vascular adhesion molecules in postmenopausal women with abdominal obesity. DESIGN: Forty women aged 51-63 yr received GH (0.67 mg/d) in a randomized, double-blind, placebo-controlled, 12-month trial. Measurements of inflammatory markers [highly sensitive C-reactive protein (CRP), IL-6, and amyloid polypeptideA] and markers of endothelial dysfunction (soluble E-selectin, vascular adhesion molecule-1, intercellular molecule-1, and matrix metalloproteinase-9) were performed at baseline and after 6 and 12 months of treatment. RESULTS: After 12 months, the mean IGF sd score was 0.9 +/- 1.5 and -0.8 +/- 0.6 in the GH and placebo groups, respectively. GH treatment reduced CRP and IL-6 levels compared with placebo (P = 0.03 and P = 0.05, respectively), whereas the markers of endothelial dysfunction were unaffected. Within the GH-treated group, a reduction was shown in CRP (4.3 +/- 4 to 3.0 +/- 3 mg/liter; P < 0.05) and in IL-6 (4.4 +/- 2 to 3.3 +/- 2 ng/liter; P < 0.01). In the GH-treated group, the decrease in CRP and IL-6 correlated with a reduction in visceral adipose tissue (r = 0.7, P < 0.001 and r = 0.5, P < 0.05, respectively). CONCLUSION: GH treatment in postmenopausal women with abdominal obesity reduced serum markers of systemic inflammation. Circulating markers of endothelial dysfunction were unaffected by treatment.

Ämnesord och genrebeteckningar

Abdominal Fat
Aged
C-Reactive Protein
metabolism
Endothelium
Vascular
drug effects
immunology
Female
Human Growth Hormone
therapeutic use
Humans
Inflammation
blood
drug therapy
Interleukin-6
blood
Middle Aged
Obesity
drug therapy
immunology
metabolism
Placebos
Postmenopause
Serum Amyloid A Protein
metabolism

Biuppslag (personer, institutioner, konferenser, titlar ...)

Andersson, Björn,1953Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xandeb (författare)
Lönn, Lars,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xlonla (författare)
Bengtsson, Bengt-Åke,1944Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xbenbe (författare)
Svensson, Johan,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xsjohc (författare)
Johannsson, Gudmundur,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xjgudn (författare)
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin (creator_code:org_t)

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Ingår i:The Journal of clinical endocrinology and metabolism: The Endocrine Society92:7, s. 2644-70021-972X1945-7197

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Av författaren/redakt...: Franco Ramos, Ce ...; Andersson, Björn ...; Lönn, Lars, 1956; Bengtsson, Bengt ...; Svensson, Johan, ...; Johannsson, Gudm ...

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