Fat distribution, lipid accumulation in the liver, and exercise capacity do not explain the insulin resistance in healthy males with a family history for type 2 diabetes.

• To explore the mechanisms for the insulin resistance associated with a family history of type 2 diabetes, we studied 16 healthy men with at least two first-degree relatives with type 2 diabetes and 16 control subjects without known heredity. They were pair-wise matched for age, body mass index, and fasting triglycerides and underwent an oral glucose tolerance test, iv glucose infusion to measure the early insulin secretion, euglycemic hyperinsulinemic clamp, computed tomography scan, 7-d food record, and a cardiopulmonary exercise test to measure peak oxygen uptake. Insulin sensitivity index was 30% lower (P = 0.02) in relatives, compared with controls, but fasting and 2-h blood glucose and first-phase insulin secretion were similar. There were no differences in mean fasting free fatty acid levels, amount of sc or visceral adipose tissue, or fat accumulation in the liver. Dietary intake and peak oxygen uptake were also similar. However, multiple regression analysis of both groups showed that fat in the liver and physical capacity were, like known heredity for type 2 diabetes, independent predictors of insulin sensitivity. Thus, lipid accumulation in the liver and physical capacity are related to insulin sensitivity, but neither of these factors nor the amount and distribution of the body fat can explain the insulin resistance associated with a family history for type 2 diabetes.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Adiponectin

Adipose Tissue

anatomy & histology

Adult

Anaerobic Threshold

physiology

Anthropometry

Body Composition

physiology

Body Mass Index

Diabetes Mellitus

Type 2

genetics

Diet

Exercise

physiology

Exercise Test

Fatty Acids

Nonesterified

blood

Glucose Clamp Technique

Glucose Tolerance Test

Humans

Insulin

blood

Insulin Resistance

physiology

Intercellular Signaling Peptides and Proteins

Lipid Metabolism

Liver

metabolism

Male

Middle Aged

Phenotype

Proteins

metabolism

Regression Analysis

Triglycerides

blood

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)