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Antioxidants can in...
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Le Gal, KristellGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Sahlgrenska Cancer Center,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
(author)
Antioxidants can increase melanoma metastasis in mice.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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American Association for the Advancement of Science (AAAS),2015
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/223945
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https://gup.ub.gu.se/publication/223945URI
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https://doi.org/10.1126/scitranslmed.aad3740DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132482911URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Antioxidants in the diet and supplements are widely used to protect against cancer, but clinical trials with antioxidants do not support this concept. Some trials show that antioxidants actually increase cancer risk and a study in mice showed that antioxidants accelerate the progression of primary lung tumors. However, little is known about the impact of antioxidant supplementation on the progression of other types of cancer, including malignant melanoma. We show that administration of N-acetylcysteine (NAC) increases lymph node metastases in an endogenous mouse model of malignant melanoma but has no impact on the number and size of primary tumors. Similarly, NAC and the soluble vitamin E analog Trolox markedly increased the migration and invasive properties of human malignant melanoma cells but did not affect their proliferation. Both antioxidants increased the ratio between reduced and oxidized glutathione in melanoma cells and in lymph node metastases, and the increased migration depended on new glutathione synthesis. Furthermore, both NAC and Trolox increased the activation of the small guanosine triphosphatase (GTPase) RHOA, and blocking downstream RHOA signaling abolished antioxidant-induced migration. These results demonstrate that antioxidants and the glutathione system play a previously unappreciated role in malignant melanoma progression.
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Ibrahim, Mohamed XGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Sahlgrenska Cancer Center,Institute of Medicine, Department of Molecular and Clinical Medicine
(author)
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Wiel, Clotilde,1987Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Sahlgrenska Cancer Center,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xwiecl
(author)
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Sayin, Volkan I.,1983Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Wallenberglaboratoriet,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Wallenberg Laboratory(Swepub:gu)xsayvo
(author)
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Akula, Murali KGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Sahlgrenska Cancer Center,Institute of Medicine, Department of Molecular and Clinical Medicine
(author)
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Karlsson, Christin,1956Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xkarlc
(author)
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Dalin, Martin,1982Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xdalim
(author)
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Akyürek, Levent,1966Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xakyle
(author)
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Lindahl, Per,1967Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Wallenberg Laboratory,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xlindp
(author)
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Nilsson, Jonas A,1971Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xnijon
(author)
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Bergö, Martin,1970Karolinska Institutet,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbmarl
(author)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
(creator_code:org_t)
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In:Science Translational Medicine: American Association for the Advancement of Science (AAAS)7:3081946-62421946-6234
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