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  • Lindblom, Per,1974Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry (author)

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.

  • Article/chapterEnglish2003

Publisher, publication year, extent ...

  • 2003-08-01
  • Cold Spring Harbor Laboratory,2003

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/61642
  • https://gup.ub.gu.se/publication/61642URI
  • https://doi.org/10.1101/gad.266803DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-10797URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the pericellular space. To address the role of PDGF-B retention in vivo, we deleted the retention motif by gene targeting in mice. This resulted in defective investment of pericytes in the microvessel wall and delayed formation of the renal glomerulus mesangium. Long-term effects of lack of PDGF-B retention included severe retinal deterioration, glomerulosclerosis, and proteinuria. We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice.

Subject headings and genre

  • Alleles
  • Amino Acid Motifs
  • Amino Acid Sequence
  • Animals
  • Cell Movement
  • Endothelial Growth Factors
  • metabolism
  • Endothelium
  • Vascular
  • metabolism
  • Glomerulosclerosis
  • Focal Segmental
  • genetics
  • Intercellular Signaling Peptides and Proteins
  • metabolism
  • Kidney
  • physiology
  • Lymphokines
  • metabolism
  • Mice
  • Microcirculation
  • metabolism
  • Microscopy
  • Fluorescence
  • Models
  • Genetic
  • Molecular Sequence Data
  • Mutation
  • Pericytes
  • metabolism
  • Phenotype
  • Platelet-Derived Growth Factor
  • metabolism
  • Protein Structure
  • Tertiary
  • Proteinuria
  • genetics
  • Proto-Oncogene Proteins c-sis
  • genetics
  • metabolism
  • Retina
  • metabolism
  • physiology
  • Retinal Degeneration
  • genetics
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Alleles

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gerhardt, Holger,1969Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry (author)
  • Liebner, Stefan (author)
  • Abramsson, Alexandra,1973Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry(Swepub:gu)xabram (author)
  • Enge, Maria,1970Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry(Swepub:gu)xenmar (author)
  • Hellström, Mats (author)
  • Bäckström, GudrunLudwiginstitutet för Cancerforskning (author)
  • Fredriksson, SimonUppsala universitet,Institutionen för genetik och patologi (author)
  • Landegren, UlfUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ulfland (author)
  • Nyström, Henrik,1977Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xnyshe (author)
  • Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xbgort (author)
  • Dejana, Elisabetta (author)
  • Östman, ArneLudwiginstitutet för Cancerforskning (author)
  • Lindahl, Per,1967Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicinsk och fysiologisk kemi,Wallenberg Laboratory,Institute of Medical Biochemistry(Swepub:gu)xlindp (author)
  • Betsholtz, Christer,1959Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry (author)
  • Göteborgs universitetInstitutionen för medicinsk och fysiologisk kemi (creator_code:org_t)

Related titles

  • In:Genes & development: Cold Spring Harbor Laboratory17:15, s. 1835-400890-93691549-5477

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