Cerebrospinal fluid levels of total-tau, phospho-tau and A beta 42 predicts development of Alzheimer's disease in patients with mild cognitive impairment.

Cerebrospinal fluid (CSF) biochemical diagnostic markers may be valuable to help in the diagnosis early in the course of Alzheimer's disease (AD), especially in the phase before clinically overt dementia, i.e. in patients with mild cognitive impairment (MCI). We studied 44 patients with MCI who, at 1-year follow-up investigation, had progressed to AD with dementia, and 32 controls. Three CSF biomarkers related to the central pathogenic processes in AD were analysed, including CSF total-tau (T-tau) (as a marker for neuronal degeneration), CSF phospho-tau (P-tau) (as a marker for hyperphosphorylation of tau and possibly for the formation of neurofibrillary tangles), and CSF A beta 42 (as a marker for A beta metabolism, and possibly for the formation of senile plaques). At baseline, 35/44 (79.5%) of the MCI patients had high CSF T-tau, 31/44 (70.4%) high CSF P-tau, while 34/44 (77.3%) had low CSF-A beta 42 levels. The positive likelihood ratio was 8.45 for CSF T-tau, 7.49 for CSF P-tau and 8.20 for CSF A beta 42. These findings suggest that these CSF-markers are abnormal before the onset of clinical dementia, and that they may help to identify MCI patients that will progress to AD. CSF diagnostic markers will be especially important when drugs with potential effects on the progression of AD (e.g. gamma-secretase inhibitors) will reach the clinical phase.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Aged
Alzheimer Disease
cerebrospinal fluid
complications
diagnosis
Amyloid beta-Protein
cerebrospinal fluid
Biological Markers
cerebrospinal fluid
Cognition Disorders
cerebrospinal fluid
diagnosis
Dementia
cerebrospinal fluid
complications
diagnosis
Diagnosis
Differential
Disease Progression
Follow-Up Studies
Humans
Likelihood Functions
Middle Aged
Neuropsychological Tests
Peptide Fragments
cerebrospinal fluid
Phosphorylation
Predictive Value of Tests
Sensitivity and Specificity
tau Proteins
cerebrospinal fluid

Vanmechelen, Eugeen (författare)
Vanderstichele, Hugo (författare)
Davidsson, Pia,1962Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience(Swepub:gu)xdavpi (författare)
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience(Swepub:gu)xbleka (författare)
Karolinska InstitutetInstitutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap (creator_code:org_t)

Ingår i:Acta neurologica Scandinavica. Supplementum: Hindawi Limited179, s. 47-510065-14270001-6314

Av författaren/redakt...: Andreasen, Niels; Vanmechelen, Eug ...; Vanderstichele, ...; Davidsson, Pia, ...; Blennow, Kaj, 19 ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.