Regional ventilation and distribution of emphysema - a quantitative comparison

Johansson, Åke,1950Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine (författare)

The distribution of ventilation and emphysema throughout the lung was compared in 20 emphysematous patients who were candidates for lung volume reduction surgery. Ventilation distribution among 1.6-cm-high stripe regions was obtained in supine position by planar gamma camera scintigraphy after inhalation of technegas(R). Results from nine healthy subjects provided normal stripe count rates. Patient count rates were expressed as the difference from predicted normal stripe count rate (DeltaSVI). Thus, DeltaSVI is a relative index of abnormal ventilation. Emphysema was assessed quantitatively by a density mask method on corresponding slices of high resolution computed tomography (HRCT). The results show that in the majority of patients, there is a highly significant relationship between the degree of stripe hypoventilation and the amount of distribution of emphysema, but in some patients no such relationship is found. We speculate that the distribution of airway obstruction not necessarily follows the distribution of emphysema, which could explain the lack of concordance between ventilation and emphysema distribution in some patients. We conclude that ventilation scintigraphy contains complementary information to lung HRCT.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Adult
Aerosols/diagnostic use/pharmacokinetics
Humans
Lung/metabolism/*radiography/*radionuclide imaging
Male
Middle Aged
Pulmonary Emphysema/metabolism/*radiography/*radionuclide imaging
*Pulmonary Ventilation
Radiopharmaceuticals/diagnostic use/pharmacokinetics
Sodium Pertechnetate Tc 99m/*diagnostic use/pharmacokinetics
Statistics
Subtraction Technique
Tissue Distribution

Vikgren, Jenny,1957Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiologi,Institute of Selected Clinical Sciences, Department of Radiology(Swepub:gu)xvikje (författare)
Moonen, MichaelaGothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xmoomi (författare)
Tylén, Ulf,1938Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiologi,Institute of Selected Clinical Sciences, Department of Radiology(Swepub:gu)xtyleu (författare)
Bake, Björn,1939Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology(Swepub:gu)xbakbj (författare)
Göteborgs universitetInstitutionen för invärtesmedicin (creator_code:org_t)

Av författaren/redakt...: Johansson, Åke, ...; Vikgren, Jenny, ...; Moonen, Michaela; Tylén, Ulf, 1938; Bake, Björn, 193 ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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