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Sökning: L773:1471 2202 > Dozmorov Mikhail 1973 > Slowly developing d...
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- Dozmorov, Mikhail,1973Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för medicinsk fysik,Institute of Physiology and Pharmacology, Dept of Medical Biophysics (författare)
Slowly developing depression of N-methyl-D-aspartate receptor mediated responses in young rat hippocampi.
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
- Springer Science and Business Media LLC,2004
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/65395
- https://gup.ub.gu.se/publication/65395URI
- https://doi.org/10.1186/1471-2202-5-26DOI
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- Språk:engelska
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Anmärkningar
- BACKGROUND: Activation of N-methyl-D-aspartate (NMDA) type glutamate receptors is essential in triggering various forms of synaptic plasticity. A critical issue is to what extent such plasticity involves persistent changes of glutamate receptor subtypes and many prior studies have suggested a main role for alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in mediating the effect. Our previous work in hippocampal slices revealed that, under pharmacological unblocking of NMDA receptors, both AMPA and NMDA receptor mediated responses undergo a slowly developing depression. In the present study we have further addressed this phenomenon, focusing on the contribution via NMDA receptors. Pharmacologically isolated NMDA receptor mediated excitatory postsynaptic potentials (EPSPs) were recorded for two independent synaptic pathways in CA1 area using perfusion with low Mg2+ (0.1 mM) to unblock NMDA receptors. RESULTS: Following unblocking of NMDA receptors, there was a gradual decline of NMDA receptor mediated EPSPs for 2-3 hours towards a stable level of ca. 60-70 % of the maximal size. If such an experimental session was repeated twice in the same pathway with a period of NMDA receptor blockade in between, the depression attained in the first session was still evident in the second one and no further decay occurred. The persistency of the depression was also validated by comparison between pathways. It was found that the responses of a control pathway, unstimulated in the first session of receptor unblocking, behaved as novel responses when tested in association with the depressed pathway under the second session. In similar experiments, but with AP5 present during the first session, there was no subsequent difference between NMDA EPSPs. CONCLUSIONS: Our findings show that merely evoking NMDA receptor mediated responses results in a depression which is input specific, induced via NMDA receptor activation, and is maintained for several hours through periods of receptor blockade. The similarity to key features of long-term depression and long-term potentiation suggests a possible relation to these phenomena. Additionally, a short term potentiation and decay (<5 min) were observed during sudden start of NMDA receptor activation supporting the idea that NMDA receptor mediated responses are highly plastic.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- Animals
- Animals
- Newborn
- Excitatory Postsynaptic Potentials
- Hippocampus
- growth & development
- physiology
- Kinetics
- Long-Term Synaptic Depression
- Rats
- Rats
- Sprague-Dawley
- Receptors
- N-Methyl-D-Aspartate
- antagonists & inhibitors
- metabolism
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Li, Rui,1975Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för medicinsk fysik,Institute of Physiology and Pharmacology, Dept of Medical Biophysics (författare)
- Xu, Hui-PingGothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för medicinsk fysik,Institute of Physiology and Pharmacology, Dept of Medical Biophysics (författare)
- Jilderos, Barbro,1947Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för medicinsk fysik,Institute of Physiology and Pharmacology, Dept of Medical Biophysics(Swepub:gu)xjilba (författare)
- Wigström, Holger,1946Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för medicinsk fysik,Institute of Physiology and Pharmacology, Dept of Medical Biophysics(Swepub:gu)xwigho (författare)
- Göteborgs universitetInstitutionen för fysiologi och farmakologi, Avdelningen för medicinsk fysik (creator_code:org_t)
Sammanhörande titlar
- Ingår i:BMC neuroscience: Springer Science and Business Media LLC5:11471-2202
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