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Variation in the CT...
Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease.
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Popat, S (author)
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Hearle, N (author)
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- Högberg, Lotta (author)
- Linköpings universitet,Hälsouniversitetet,Pediatrik
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Braegger, C P (author)
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O'Donoghue, D (author)
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- Fälth-Magnusson, Karin, 1949- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn
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Holmes, G K T (author)
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Howdle, P D (author)
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Jenkins, H (author)
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Johnston, S (author)
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Kennedy, N P (author)
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Kumar, P J (author)
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Logan, R F A (author)
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Marsh, M N (author)
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Mulder, C J (author)
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- Torinsson Naluai, Åsa, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children
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- Sjoberg, K (author)
- Östergötlands Läns Landsting,Barn
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- Stenhammar, Lars, 1939- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn
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Walters, J R F (author)
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Jewell, D P (author)
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Houlston, R S (author)
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Annals of human genetics. - 0003-4800 .- 1469-1809. ; 66:Pt 2, s. 125-37
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Susceptibility to coeliac disease involves HLA and non-HLA-linked genes. The CTLA4/CD28 gene region encodes immune regulatory T-cell surface molecules and is a strong candidate as a susceptibility locus. We evaluated CTLA4/CD28 in coeliac disease by genetic linkage and association and combined our findings with published studies through a meta-analysis. 116 multiplex families were genotyped across CTLA4/CD28 using eight markers. The contribution of CTLA4/CD28 to coeliac disease was assessed by non-parametric linkage and association analyses. Seven studies were identified that had evaluated the relationship between CTLA4/CD28 and coeliac disease and a pooled analysis of data undertaken. In our study there was evidence for a relationship between variation in the CTLA4/CD28 region and coeliac disease by linkage and association analyses. However, the findings did not attain formal statistical significance (p = 0.004 and 0.039, respectively). Pooling findings with published results showed significant evidence for linkage (504 families) and association (940 families): p values, 0.0001 and 0.0014 at D2S2214, respectively, and 0.0008 and 0.0006 at D2S116, respectively. These findings suggest that variation in the CD28/CTLA4 gene region is a determinant of coeliac disease susceptibility. Dissecting the sequence variation underlying this relationship will depend on further analyses utilising denser sets of markers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Antigens
- CD
- Antigens
- CD28
- genetics
- Antigens
- Differentiation
- genetics
- Celiac Disease
- epidemiology
- genetics
- immunology
- Child
- Child
- Preschool
- Chromosomes
- Human
- Pair 2
- genetics
- Europe
- epidemiology
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Immunoconjugates
- Infant
- Linkage (Genetics)
- Male
- Middle Aged
- Risk
- Statistics
- Nonparametric
- T-Lymphocytes
- immunology
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Popat, S
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Hearle, N
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Högberg, Lotta
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Braegger, C P
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O'Donoghue, D
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Fälth-Magnusson, ...
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show more...
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Holmes, G K T
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Howdle, P D
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Jenkins, H
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Johnston, S
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Kennedy, N P
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Kumar, P J
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Logan, R F A
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Marsh, M N
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Mulder, C J
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Torinsson Naluai ...
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Sjoberg, K
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Stenhammar, Lars ...
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Walters, J R F
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Jewell, D P
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Houlston, R S
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
- Articles in the publication
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Annals of human ...
- By the university
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University of Gothenburg
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Linköping University