Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease.

Susceptibility to coeliac disease involves HLA and non-HLA-linked genes. The CTLA4/CD28 gene region encodes immune regulatory T-cell surface molecules and is a strong candidate as a susceptibility locus. We evaluated CTLA4/CD28 in coeliac disease by genetic linkage and association and combined our findings with published studies through a meta-analysis. 116 multiplex families were genotyped across CTLA4/CD28 using eight markers. The contribution of CTLA4/CD28 to coeliac disease was assessed by non-parametric linkage and association analyses. Seven studies were identified that had evaluated the relationship between CTLA4/CD28 and coeliac disease and a pooled analysis of data undertaken. In our study there was evidence for a relationship between variation in the CTLA4/CD28 region and coeliac disease by linkage and association analyses. However, the findings did not attain formal statistical significance (p = 0.004 and 0.039, respectively). Pooling findings with published results showed significant evidence for linkage (504 families) and association (940 families): p values, 0.0001 and 0.0014 at D2S2214, respectively, and 0.0008 and 0.0006 at D2S116, respectively. These findings suggest that variation in the CD28/CTLA4 gene region is a determinant of coeliac disease susceptibility. Dissecting the sequence variation underlying this relationship will depend on further analyses utilising denser sets of markers.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
Adolescent
Adult
Aged
Antigens
CD
Antigens
CD28
genetics
Antigens
Differentiation
genetics
Celiac Disease
epidemiology
genetics
immunology
Child
Child
Preschool
Chromosomes
Human
Pair 2
genetics
Europe
epidemiology
Female
Genetic Markers
Genetic Predisposition to Disease
Genotype
Humans
Immunoconjugates
Infant
Linkage (Genetics)
Male
Middle Aged
Risk
Statistics
Nonparametric
T-Lymphocytes
immunology
MEDICINE

Hearle, N (författare)
Högberg, LottaLinköpings universitet,Hälsouniversitetet,Pediatrik(Swepub:liu)lotho28 (författare)
Braegger, C P (författare)
O'Donoghue, D (författare)
Fälth-Magnusson, Karin,1949-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn(Swepub:liu)karfa12 (författare)
Holmes, G K T (författare)
Howdle, P D (författare)
Jenkins, H (författare)
Johnston, S (författare)
Kennedy, N P (författare)
Kumar, P J (författare)
Logan, R F A (författare)
Marsh, M N (författare)
Mulder, C J (författare)
Torinsson Naluai, Åsa,1968Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children(Swepub:gu)xnalas (författare)
Sjoberg, KÖstergötlands Läns Landsting,Barn (författare)
Stenhammar, Lars,1939-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn(Swepub:liu)larst66 (författare)
Walters, J R F (författare)
Jewell, D P (författare)
Houlston, R S (författare)
Linköpings universitetHälsouniversitetet (creator_code:org_t)

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