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(LAR1:gu) pers:(Wallin Anders 1950) pers:(Blennow Kaj 1958) srt2:(2005-2009)
 

Search: (LAR1:gu) pers:(Wallin Anders 1950) pers:(Blennow Kaj 1958) srt2:(2005-2009) > Kinesin gene variab...

  • Andersson, Malin E,1978Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry (author)

Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease.

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/65989
  • https://gup.ub.gu.se/publication/65989URI
  • https://lup.lub.lu.se/record/648422URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:115583371URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Kinesin is a microtubule-associated motor protein that transports Alzheimer-associated amyloid precursor protein (APP) in neurons. In animal models, impaired kinesin-mediated APP transport seems to enhance formation of the neurotoxic 42 amino acid fragment of beta-amyloid (A beta 42). In man, one study suggests that a polymorphism (rs8702, 56,836G>C) in the kinesin light chain 1 gene (KNS2) may affect the risk of Alzheimer's disease (AD). To further assess KNS2 as a susceptibility gene for AD we analyzed 802 patients with sporadic AD and 286 controls, 134 longitudinally followed patients with mild cognitive impairment (MCI) and 39 cognitively stable controls for the rs8702 polymorphism. The rs8702 polymorphism did not influence risk of AD (p=0.46). However, rs8702 interacted with APOE epsilon 4 carrier status in AD (p=0.006) and influenced cerebrospinal fluid levels of hyperphosphorylated tau in MCI patients who converted to AD during follow-up (p=0.018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis.

Subject headings and genre

  • MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
  • MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
  • Aged
  • Aged
  • 80 and over
  • Alzheimer Disease
  • genetics
  • metabolism
  • pathology
  • Apolipoproteins E
  • genetics
  • Case-Control Studies
  • Disease Progression
  • Female
  • Gene Frequency
  • Humans
  • Male
  • Microtubule-Associated Proteins
  • genetics
  • Middle Aged
  • Phosphorylation
  • Polymorphism
  • Single Nucleotide
  • Protein Kinases
  • metabolism
  • Variation (Genetics)
  • physiology
  • tau Proteins
  • metabolism
  • apolipoprotein
  • biomarkers
  • polymorphism
  • Alzheimer's disease
  • kinesin
  • E
  • axonal transport

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sjölander, Annica,1969Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institutionen för vårdvetenskap och hälsa,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Health and Care Sciences(Swepub:gu)xjannq (author)
  • Andreasen, NielsKarolinska Institutet (author)
  • Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)psyk-lmi (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn (author)
  • Bogdanovic, NenadKarolinska Institutet (author)
  • Jern, Christina,1962Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xjerch (author)
  • Jood, Katarina,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xjooka (author)
  • Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xwaand (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:International journal of molecular medicine20:2, s. 233-91107-37561791-244X

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