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  • Shin, J. H.Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada (author)

IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Springer Science and Business Media LLC,2007

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/66312
  • https://gup.ub.gu.se/publication/66312URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14463URI
  • https://doi.org/10.1038/sj.gene.6364413DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-108702URI
  • https://lup.lub.lu.se/record/1140902URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:115877410URI

Supplementary language notes

  • Language:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • In a large case-control study of Swedish incident type I diabetes patients and controls, 0-34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 x 10(-13)) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 x 10(-5)) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Janer, M.Institute for Systems Biology, Seattle, WA, USA (author)
  • McNeney, B.Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada (author)
  • Blay, S.Karolinska Institutet (author)
  • Deutsch, K.Institute for Systems Biology, Seattle, WA, USA (author)
  • Sanjeevi, C. B. (author)
  • Kockum, I.Karolinska Institutet (author)
  • Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale (author)
  • Graham, J.Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada (author)
  • Arnqvist, H.Linköpings universitet,Cellbiologi,Hälsouniversitetet (author)
  • Björck, E. (author)
  • Eriksson, J. (author)
  • Nystrom, L. (author)
  • Ohlson, L. O. (author)
  • Schersten, B. (author)
  • Östman, J. (author)
  • Aili, M. (author)
  • Baath, L. E. (author)
  • Carlsson, E. (author)
  • Edenwall, H. (author)
  • Forsander, Gun,1951Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xfgunj (author)
  • Granström, B. W. (author)
  • Gustavsson, I. (author)
  • Hanas, R. (author)
  • Hellenberg, L. (author)
  • Hellgren, H. (author)
  • Holmberg, E. (author)
  • Hornell, H. (author)
  • Ivarsson, S. A. (author)
  • Johansson, C. (author)
  • Jonsell, G. (author)
  • Kockum, K. (author)
  • Lindblad, B. (author)
  • Lindh, A. (author)
  • Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (author)
  • Myrdal, U. (author)
  • Neiderud, J. (author)
  • Segnestam, K. (author)
  • Sjöblad, S. (author)
  • Skogsberg, L. (author)
  • Stromberg, L. (author)
  • Stahle, U. (author)
  • Thalme, B. (author)
  • Tullus, K. (author)
  • Tuvemo, TUppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson(Swepub:uu)torstuve (author)
  • Wallensteen, M. (author)
  • Westphal, O. (author)
  • Aman, J.Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson (author)
  • Diabetes Incidence in Sweden Study Group, The (author)
  • Swedish Childhood Diabetes Study Group, The (author)
  • Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, CanadaInstitute for Systems Biology, Seattle, WA, USA (creator_code:org_t)

Related titles

  • In:Genes Immun: Springer Science and Business Media LLC8:6, s. 503-121466-48791476-5470

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