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  • Sedimbi, S. K.Karolinska Institutet (author)

SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-06-07
  • Springer Science and Business Media LLC,2007

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/66317
  • https://gup.ub.gu.se/publication/66317URI
  • https://doi.org/10.1038/sj.gene.6364406DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-8961URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14458URI
  • https://lup.lub.lu.se/record/1140507URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-108701URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:115877412URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Group Author(s): Swedish Childhood Diabetes
  • SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.

Subject headings and genre

  • MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
  • MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
  • Adolescent
  • Adult
  • Alleles
  • Case-Control Studies
  • Child
  • Child
  • Preschool
  • Cohort Studies
  • Diabetes Mellitus
  • Type 1/*genetics/immunology
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • HLA-DR3 Antigen/*genetics/immunology
  • HLA-DR4 Antigen/*genetics/immunology
  • Haplotypes
  • Humans
  • Infant
  • Infant
  • Newborn
  • Male
  • Polymorphism
  • Single Nucleotide
  • Small Ubiquitin-Related Modifier Proteins/*genetics/immunology
  • Sweden
  • Adolescent
  • MEDICINE

Added entries (persons, corporate bodies, meetings, titles ...)

  • Luo, X. R.Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (author)
  • Sanjeevi, C. B.Karolinska Institutet (author)
  • Lernmark, Ake (author)
  • Landin-Olsson, MonaLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-mla (author)
  • Arnqvist, H.Linköpings universitet,Cellbiologi,Hälsouniversitetet (author)
  • Björck, E. (author)
  • Nyström, L. (author)
  • Ohlson, L. O. (author)
  • Schersten, B. (author)
  • Östman, J. (author)
  • Aili, M. (author)
  • Baath, L. E. (author)
  • Carlsson, E. (author)
  • Edenwall, H. (author)
  • Forsander, Gun,1951Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xfgunj (author)
  • Granström, B. W. (author)
  • Gustavsson, I. (author)
  • Hanas, R. (author)
  • Hellenberg, L. (author)
  • Hellgren, H. (author)
  • Holmberg, E. (author)
  • Hornell, H. (author)
  • Ivarsson, S. A. (author)
  • Johansson, C. (author)
  • Jonsell, G. (author)
  • Kockum, K. (author)
  • Lindblad, B. (author)
  • Lindh, A. (author)
  • Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (author)
  • Myrdal, U. (author)
  • Neiderud, J. (author)
  • Segnestam, K. (author)
  • Sjöblad, S. (author)
  • Skogsberg, L. (author)
  • Strömberg, L. (author)
  • Stahle, U. (author)
  • Thalme, B. (author)
  • Tullus, K. (author)
  • Tuvemo, TorstenUppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson(Swepub:uu)torstuve (author)
  • Wallensteen, M. (author)
  • Westphal, Otto,1935Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xwesot (author)
  • Dahlquist, GiselaUmeå universitet,Pediatrik(Swepub:umu)gida0001 (author)
  • Aman, J.Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forksning/Gustafsson (author)
  • Karolinska InstitutetDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Genes Immun: Springer Science and Business Media LLC8:6, s. 518-211466-48791476-5470

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