Recent outcomes and perspectives of the application of bone morphogenetic proteins in implant dentistry.

• BACKGROUND: Since the discovery of bone morphogenetic proteins (BMPs), the number of related studies has increased substantially, and more recent outcomes have cast encouraging perspectives on their use in reconstructive surgery. PURPOSE: The aim of the present review was to summarize the present knowledge about the use of BMPs in conjunction with dental implants based on the literature. MATERIALS AND METHODS: Scientific articles dealing with the use of growth factors and bone healing with or without dental implants were searched for on MEDLINE and critically scrutinized. RESULTS: Thirty-nine scientific reports formed the base for the present review. Whereas the osteoinductive capability of BMPs is well documented, studies on their effects in implant dentistry are still incipient. Preclinical and clinical studies did not show outstandingly good outcomes of the application of BMPs compared with conventional treatments or controls. CONCLUSIONS: The number of studies in the field of dental implantology in which BMPs have been used is still too small for establishing clinical protocols of their use in order to improve a recipient bone bed prior to implant placement or to enhance the integration process of an implant.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

Alveolar Ridge Augmentation

Animals

Bone Density

drug effects

Bone Morphogenetic Proteins

classification

pharmacology

therapeutic use

Dental Implantation

Endosseous

Dental Implants

Humans

Osseointegration

Osteogenesis

drug effects

Transforming Growth Factor beta

pharmacology

therapeutic use

Treatment Outcome

Wound Healing

drug effects

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)