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  • Behboudi, Afrouz,1967Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden (författare)

Detailed chromosomal and radiation hybrid mapping in the proximal part of rat Chromosome 10 and gene order comparison with mouse and human.

  • Artikel/kapitelEngelska2002

Förlag, utgivningsår, omfång ...

  • 2014-02-05
  • Springer Science and Business Media LLC,2002

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/68438
  • https://gup.ub.gu.se/publication/68438URI
  • https://doi.org/10.1007/s00335-001-2153-4DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23016URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1939293URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-7506URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • We thank Prof. Göran Levan for carefully reading the manuscript, adding invaluable insights and comments; Dr. Khalil Helou for valuable remarks on FISH results; Dr. Stefan Imreh for helping with sequence data comparisons; and Elisabet Magnusson and Brita Bjönness for technical assistance. The work was supported by grants from the Swedish Medical Research Council, the Carl Trygger Foundation, the Wallenberg Foundation, the IngaBritt and Arne Lundberg Research Foundation, the SWEGENE Foundation, the Royal Swedish Academy of Sciences, the Erik Philip-Sörensen Foundation, and the Royal and Hvitfeldtska Foundation.
  • The rat provides valuable and sometimes unique models of human complex diseases. To fully exploit the rat models in biomedical research, it is important to have access to detailed knowledge of the rat genome organization as well as its relation to the human genome. Rat Chromosome 10 (RNO10) harbors several important cancer-related genes. Deletions in the proximal part of RNO10 were repeatedly found in a rat model for endometrial cancer. To identify functional and positional candidate genes in the affected region, we used radiation hybrid (RH) mapping and single- and dual-color fluorescence in situ hybridization (FISH) techniques to construct a detailed chromosomal map of the proximal part of RNO10. The regional localization of 14 genes, most of them cancer-related ( Grin2a, Gspt1, Crebbp, Gfer, Tsc2, Tpsb1, Il9r, Il4, Irf1, Csf2, Sparc, Tp53, Thra1, Gh1), and of five microsatellite markers ( D10Mit10, D10Rat42, D10Rat50, D10Rat72, and D10Rat165) was determined on RNO10. For a fifteenth gene, Ppm1b, which had previously been assigned to RNO10, the map position was corrected to RNO6q12-q13.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Roshani, Leyla,1972Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden(Swepub:gu)xrosle (författare)
  • Kost-Alimova, MarijaKarolinska Institutet (författare)
  • Sjöstrand, EleonorGothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden (författare)
  • Montelius-Alatalo, KerstinGothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden (författare)
  • Röhme, Dan,1944Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden(Swepub:gu)xrohda (författare)
  • Klinga-Levan, Karin,1951-Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden(Swepub:his)klik (författare)
  • Ståhl, Fredrik,1956Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden(Swepub:hb)fhl (författare)
  • Göteborgs universitetInstitutionen för cell- och molekylärbiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Mammalian genome : official journal of the International Mammalian Genome Society: Springer Science and Business Media LLC13:6, s. 302-90938-89901432-1777
  • Ingår i:Mammalian Genome: Springer Science and Business Media LLC13:6, s. 302-91432-1777

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