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Results of Sacral N...
Results of Sacral Neuromodulation Therapy for Urinary Voiding Dysfunction: Outcomes of a Prospective, Worldwide Clinical Study
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van Kerrebroeck, PE (författare)
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van Voskuilen, AC (författare)
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Heesakkers, JP (författare)
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Nijholt, Lycklama A (författare)
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Siegel, S (författare)
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Jonas, U (författare)
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Fowler, CJ (författare)
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- Fall, Magnus, 1941 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Gajewski, JB (författare)
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Hassouna, MM (författare)
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Cappellano, F (författare)
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Elhilali, MM (författare)
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Milam, DF (författare)
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Das, AK (författare)
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Dijkema, HE (författare)
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Van den Hombergh, U (författare)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2007
- 2007
- Engelska.
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Ingår i: Journal of Urology. - : Ovid Technologies (Wolters Kluwer Health). - 0022-5347 .- 1527-3792. ; 178:5, s. 2029-2034
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose This 5-year, prospective, multicenter trial evaluated the long-term safety and efficacy of sacral neuromodulation in patients with refractory urge incontinence, urgency frequency and retention. Materials and Methods A total of 17 centers worldwide enrolled 163 patients (87% female). Following test stimulation 11 patients declined implantation and 152 underwent implantation using InterStim®. Of those treated with implantation 96 (63.2%) had urge incontinence, 25 (16.4%) had urgency frequency and 31 (20.4%) had retention. Voiding diaries were collected annually for 5 years. Clinical success was defined as 50% or greater improvement from baseline in primary voiding diary variable(s). Results Data for all implanted cases were reported. For patients with urge incontinence mean leaking episodes per day decreased from 9.6 ± 6.0 to 3.9 ± 4.0 at 5 years. For patients with urgency frequency mean voids per day decreased from 19.3 ± 7.0 to 14.8 ± 7.6, and mean volume voided per void increased from 92.3 ± 52.8 to 165.2 ± 147.7 ml. For patients with retention the mean volume per catheterization decreased from 379.9 ± 183.8 to 109.2 ± 184.3 ml, and the mean number of catheterizations decreased from 5.3 ± 2.8 to 1.9 ± 2.8. All changes were statistically significant (p <0.001). No life threatening or irreversible adverse events occurred. In 102 patients 279 device or therapy related adverse events were observed. At 5 years after implantation 68% of patients with urge incontinence, 56% with urgency frequency and 71% with retention had successful outcomes. Conclusions This long-term study demonstrates that InterStim therapy is safe and effective for restoring voiding in appropriately selected cases refractory to other forms of treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- electric stimulation therapy; urination disorders; urinary bladder
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van Kerrebroeck, ...
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van Voskuilen, A ...
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Heesakkers, JP
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Nijholt, Lycklam ...
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Siegel, S
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Jonas, U
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visa fler...
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Fowler, CJ
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Fall, Magnus, 19 ...
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Gajewski, JB
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Hassouna, MM
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Cappellano, F
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Elhilali, MM
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Milam, DF
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Das, AK
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Dijkema, HE
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Van den Hombergh ...
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visa färre...
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Göteborgs universitet