Search: onr:"swepub:oai:gup.ub.gu.se/69361" >
Mechanisms of incre...
-
Millqvist, Eva,1949Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
(author)
Mechanisms of increased airway sensitivity to occupational chemicals and odors.
- Article/chapterEnglish2008
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/69361
-
https://gup.ub.gu.se/publication/69361URI
-
https://doi.org/10.1097/ACI.0b013e3282f647ecDOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
PURPOSE OF REVIEW: Airway symptoms induced by chemicals and odors are common problems that are also reported after contact with substances normally regarded as nontoxic. This article reviews current findings and opinions regarding mechanisms of increased airway sensitivity to occupational chemicals and odors. RECENT FINDINGS: Individuals exposed to organic solvents during work had more nasal irritation and lower threshold to pyridine odor compared with a nonexposed control group. Six percentage of a general population in Sweden had pronounced airway chemical sensitivity and augmented capsaicin cough sensitivity, known to reflect the sensory nerve reactivity of the airways. The cough sensitivity was associated with changed levels of nerve growth factor in nasal lavage and such patients had longstanding symptoms influencing their working capacity. Positron emission tomography activation studies with several different odorants showed in patients with odor-associated symptoms an odorant-related increase in activation of the anterior cingulate cortex and cuneus-precuneus in comparison with a control group. SUMMARY: In subgroups of individuals with airway symptoms induced by chemicals and odors, there seems to be a sustainable physiological mechanism behind the reactions. An increased vulnerability to stress cannot be neglected as a confounding factor in some sensitive individuals.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin
(creator_code:org_t)
Related titles
-
In:Current opinion in allergy and clinical immunology8:2, s. 135-91528-4050
Internet link
Find in a library
To the university's database