Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families

Adamovic, Svetlana,1965Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg (author)

The first genome-wide association study performed in a UK coeliac disease (CD) case-control cohort revealed association with a linkage disequilibrium block containing the KIAA1109/Tenr/IL2/IL21 genes. Also recently, an association with a non-synonymous polymorphism in Fcitalic gammaRIIa (CD32a) was reported in CD with an unusually strong P-value. We aimed to replicate the reported associations with the single nucleotide polymorphisms rs13119723 A>G and rs6822844 G>T in the KIAA1109/Tenr/IL2/IL21 region and rs1801274 G>A in the Fcitalic gammaRIIa gene in a family sample consisting of 325 Swedish/Norwegian families using the robust transmission disequilibrium test. The family sample used in this study included 100 families with two or more children affected by CD and 225 families with one affected child. We could confirm significant association between the polymorphisms rs13119723 A>G and rs6822844 G>T located in the KIAA1109/Tenr/IL2/IL21 region and CD (P-value 0.001 and 0.002, respectively). However, we found no association with the Fcitalic gammaRIIa rs1801274 G>A polymorphism (P-value=0.3). In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region.

amundsen, siljaUniversitetet i Oslo,University of Oslo (author)
Lie, Benedicte A (author)
Gudjonsdottir, Audur,1959Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital(Swepub:gu)xgudau (author)
Ascher, Henry,1953Nordiska Hogskolan for folkhalsovetenskap,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital(Swepub:gu)xasche (author)
Ek, Johan (author)
van Heel, David AQueen Mary University of London (author)
Nilsson, Staffan,1956Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg(Swepub:cth)staffan (author)
Sollid, Ludvig MUniversitetet i Oslo,University of Oslo (author)
Torinsson Naluai, Åsa,1968Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg(Swepub:gu)xnalas (author)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik (creator_code:org_t)

In:Genes and immunity: Springer Science and Business Media LLC9:4, s. 364-3671466-48791476-5470

By the author/editor: Adamovic, Svetla ...; amundsen, silja; Lie, Benedicte A; Gudjonsdottir, A ...; Ascher, Henry, 1 ...; Ek, Johan; show more...; van Heel, David ...; Nilsson, Staffan ...; Sollid, Ludvig M; Torinsson Naluai ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

By the university: University of Gothenburg; Chalmers University of Technology

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.