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  • Marsell, RichardUppsala universitet,Ortopedi (author)

Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men.

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2008

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/75094
  • https://gup.ub.gu.se/publication/75094URI
  • https://doi.org/10.1530/EJE-07-0534DOI
  • https://lup.lub.lu.se/record/1199149URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14820URI

Supplementary language notes

  • Language:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism. Serum FGF23 is increased at later stages of chronic kidney disease due to chronic hyperphosphatemia and decreased renal clearance. Recent studies also indicate that FGF23 may directly regulate the expression of parathyroid hormone (PTH) in vitro. Therefore, the objective of the current study was to determine the relationship between FGF23, PTH, and other biochemistries in vivo in subjects with no history of renal disease. DESIGN: Serum biochemistries were measured in a subsample of the population-based Swedish part of the MrOS study. In total, 1000 Caucasian men aged 70-80 years were randomly selected from the population. METHODS: Intact FGF23, Pi, calcium, albumin, estimated glomerular filtration rate (eGFR, calculated from cystatin C), PTH, and 25(OH)D3 were measured. Association studies were performed using linear univariate and multivariate regression analyses. RESULTS: The median FGF23 level was 36.6 pg/ml, ranging from 0.63 to 957 pg/ml. There was a significant correlation between log FGF23 and eGFR (r=-0.21; P<0.00001) and log PTH (r=0.13; P<0.001). These variables remained as independent predictors of FGF23 in multivariate analysis. In addition, log PTH (beta=0.082; P<0.05) and eGFR (beta=-0.090; P<0.05) were associated with log FGF23 in subjects with eGFR>60 ml/min. Only eGFR (beta=-0.35; P<0.0001) remained as a predictor of log FGF23 in subjects with eGFR<60 ml/min. CONCLUSIONS: Serum FGF23 and PTH are associated in vivo, supporting recent findings that FGF23 directly regulates PTH expression in vitro. Additionally, eGFR is associated with FGF23 in subjects with normal or mildly impaired renal function, indicating that GFR may modulate FGF23 levels independent of serum Pi.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Grundberg, ElinUppsala universitet,Institutionen för kirurgiska vetenskaper (author)
  • Krajisnik, TijanaUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)tijkr163 (author)
  • Karlsson, MagnusLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Clinical and Molecular Osteoporosis Research Unit, Departments of Clinical Sciences and Orthopaedics, Malmö University Hospital, Lund University, 20502, Malmö, Sweden(Swepub:lu)orto-mka (author)
  • Mallmin, HansUppsala universitet,Ortopedi(Swepub:uu)hansmall (author)
  • Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xmelda (author)
  • Orwoll, Eric (author)
  • Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xohlcl (author)
  • Jonsson, Kenneth B.Uppsala universitet,Ortopedi(Swepub:uu)kennjons (author)
  • Ljunggren, ÖstenUppsala universitet,Institutionen för kirurgiska vetenskaper(Swepub:uu)osteljun (author)
  • Larsson, Tobias EUppsala universitet,Institutionen för kirurgiska vetenskaper (author)
  • Uppsala universitetOrtopedi (creator_code:org_t)

Related titles

  • In:European journal of endocrinology / European Federation of Endocrine Societies158:1, s. 125-91479-683X0804-4643

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