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Potential regional ...
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Haller, Daniel G
(författare)
Potential regional differences for the tolerability profiles of fluoropyrimidines.
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/75176
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https://gup.ub.gu.se/publication/75176URI
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https://doi.org/10.1200/JCO.2007.15.2090DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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PURPOSE: We conducted a retrospective analysis of safety data from randomized, single-agent fluoropyrimidine clinical trials (bolus fluorouracil/leucovorin [FU/LV] and capecitabine) to test the hypothesis that there are regional differences in fluoropyrimidine tolerability. METHODS: Treatment-related safety data from three phase III clinical studies were analyzed by multivariate analysis: two comparing capecitabine with bolus FU/LV in metastatic colorectal cancer (MCRC) and one comparing capecitabine plus oxaliplatin (XELOX) with bolus FU/LV as adjuvant treatment for colon cancer. The United States (US) was compared with non-US countries (all three studies) and with the rest of the world and East Asia (adjuvant study). RESULTS: In the MCRC studies (n = 1,189), more grade 3/4 adverse events (AEs; relative risk [RR], 1.77), dose reductions (RR, 1.72), and discontinuations (RR, 1.83) were reported in US versus non-US patients. Likewise, in the adjuvant colon cancer study (n = 1,864), more grade 3/4 AEs (RR, 1.47) and discontinuations (RR, 2.09) were reported in US versus non-US patients. After further dividing non-US patients into those in East Asia and the rest of the world, differential RRs for related grade 3/4 AEs, grade 4 AEs, and serious AEs were again observed, with East Asian patients having the lowest and US patients the highest RR. CONCLUSION: Regional differences exist in the tolerability profiles of fluoropyrimidines. More treatment-related toxicity was reported in the US compared with the rest of the world for bolus FU/LV and capecitabine in first-line MCRC and adjuvant colon cancer. In the adjuvant setting, a range of fluoropyrimidine tolerability was observed, with East Asian patients having the lowest, and US patients the highest, RR.
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
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Antimetabolites
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Antineoplastic
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administration & dosage
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adverse effects
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Antineoplastic Combined Chemotherapy Protocols
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adverse effects
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Chemotherapy
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Adjuvant
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Colorectal Neoplasms
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drug therapy
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ethnology
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pathology
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Deoxycytidine
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administration & dosage
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adverse effects
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analogs & derivatives
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Europe
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Far East
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Fluorouracil
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administration & dosage
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adverse effects
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analogs & derivatives
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Gastrointestinal Diseases
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chemically induced
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ethnology
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Humans
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Leucovorin
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administration & dosage
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Neoplasm Metastasis
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Neutropenia
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chemically induced
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ethnology
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Organoplatinum Compounds
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administration & dosage
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Prodrugs
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administration & dosage
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adverse effects
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Residence Characteristics
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Retrospective Studies
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Risk Assessment
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Severity of Illness Index
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Treatment Outcome
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United States
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Vitamin B Complex
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administration & dosage
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Withholding Treatment
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Cassidy, Jim
(författare)
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Clarke, Stephen J
(författare)
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Cunningham, David
(författare)
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Van Cutsem, Eric
(författare)
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Hoff, Paulo M
(författare)
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Rothenberg, Mace L
(författare)
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Saltz, Leonard B
(författare)
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Schmoll, Hans-Joachim
(författare)
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Allegra, Carmen
(författare)
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Bertino, Joseph R
(författare)
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Douillard, Jean-Yves
(författare)
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Gustavsson, Bengt,1947Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xguben
(författare)
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Milano, Gerard
(författare)
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O'Connell, Michael
(författare)
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Rustum, Youcef
(författare)
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Tabernero, Josep
(författare)
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Gilberg, Frank
(författare)
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Sirzén, Florin
(författare)
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Twelves, Chris
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of clinical oncology : official journal of the American Society of Clinical Oncology26:13, s. 2118-231527-7755
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- Av författaren/redakt...
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Haller, Daniel G
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Cassidy, Jim
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Clarke, Stephen ...
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Cunningham, Davi ...
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Van Cutsem, Eric
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Hoff, Paulo M
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visa fler...
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Rothenberg, Mace ...
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Saltz, Leonard B
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Schmoll, Hans-Jo ...
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Allegra, Carmen
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Bertino, Joseph ...
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Douillard, Jean- ...
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Gustavsson, Beng ...
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Milano, Gerard
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O'Connell, Micha ...
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Rustum, Youcef
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Tabernero, Josep
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Gilberg, Frank
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Sirzén, Florin
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Twelves, Chris
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