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Search: (L773:0012 1797 OR L773:1939 327X) srt2:(2005-2009) > (2005) > Growth hormone over...

  • Bohlooly-Yeganeh, Mohammad,1966Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology (author)

Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • 2005

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/75211
  • https://gup.ub.gu.se/publication/75211URI
  • https://lup.lub.lu.se/record/257552URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nervous system (CNS) were created to investigate the role of GH in CNS. This study shows that overexpression of GH in the CNS differentiates the effect of GH on body fat mass from that on appetite. The transgenic mice were not GH-deficient but were obese and showed increased food intake as well as increased hypothalamic expression of agouti-related protein and neuropeptide Y. GH also had an acute effect on food intake following intracerebroventricular injection of C57BL/6 mice. The transgenic mice were severely hyperinsulinemic and showed a marked hyperplasia of the islets of Langerhans. In addition, the transgenic mice displayed alterations in serum lipid and lipoprotein levels and hepatic gene expression. In conclusion, GH overexpression in the CNS results in hyperphagia-induced obesity indicating a dual effect of GH with a central stimulation of appetite and a peripheral lipolytic effect.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Olsson, Bob,1969Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xolsbo (author)
  • Bruder, Carl E G (author)
  • Lindén, Daniel,1971Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Wallenberglaboratoriet,Institute of Physiology and Pharmacology, Dept of Physiology,Wallenberg Laboratory (author)
  • Sjögren, Klara,1970Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xsjokl (author)
  • Bjursell, Mikael,1977Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xbjumi (author)
  • Egecioglu, Emil,1977Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xegeem (author)
  • Svensson, Lennart (author)
  • Brodin, Peter (author)
  • Waterton, John C (author)
  • Isaksson, Olle,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xisaol (author)
  • Sundler, FrankLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)mphy-fsu (author)
  • Ahrén, BoLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-bah (author)
  • Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl (author)
  • Oscarsson, Jan,1960Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Wallenberglaboratoriet,Institute of Physiology and Pharmacology, Dept of Physiology,Wallenberg Laboratory(Swepub:gu)xoscja (author)
  • Törnell, Jan,1960Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xtornj (author)
  • Göteborgs universitetInstitutionen för fysiologi och farmakologi, Avdelningen för fysiologi (creator_code:org_t)

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  • In:Diabetes54:1, s. 51-620012-17971939-327X

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