Sökning: id:"swepub:oai:gup.ub.gu.se/75248" >
Pharmacological tre...
-
Andersson, Niklas,1970Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,University of Gothenburg,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
(författare)
Pharmacological treatment of osteopenia induced by gastrectomy or ovariectomy in young female rats.
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
-
2009-07-08
-
Medical Journals Sweden AB,2004
Nummerbeteckningar
-
LIBRIS-ID:oai:gup.ub.gu.se/75248
-
https://gup.ub.gu.se/publication/75248URI
-
https://doi.org/10.1080/00016470412331294465DOI
-
https://research.chalmers.se/publication/75248URI
-
https://lup.lub.lu.se/record/126440URI
Kompletterande språkuppgifter
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
BACKGROUND: Both gastrectomy (GX) and ovariectomy (OVX) induce osteopenia in man and experimental animals. The present study addresses the question--can alendronate, estrogen or parathyroid hormone (PTH) be used to treat established GX- or OVX -evoked osteopenia? METHODS: Rats were GX-, OVX- or SHAM-operated 8 weeks before starting the treatment with drugs. Each group was then treated for 8 weeks with 50 microg/kg/day alendronate, 10 microg/kg/day estrogen or 75 microg/kg/day PTH(1-84); n = 8 rats/group. Peripheral Quantitative Computed Tomography (pQCT) was used to measure trabecular bone mineral density (BMD) and various cortical bone parameters. RESULTS: At killing, 16 weeks after surgery, GX and OVX rats had a greatly reduced trabecular BMD in the metaphysis of the distal femur (GX -44% and OVX -55%). Alendronate increased the trabecular BMD by 44% in GX rats and by 64% in OVX rats, while PTH increased it by 51% and 115%, respectively. However, estrogen increased the trabecular BMD in GX rats (35%), but not in OVX rats (15%, not significant). Cortical bone parameters were adversely (but moderately) affected by GX, but not by OVX or by treatment with the three drugs. INTERPRETATION: Alendronate, estrogen and PTH restored the trabecular bone loss in rats with an established GX-evoked osteopenia. In contrast, alendronate and PTH, but not estrogen, restored the trabecular bone loss after OVX. Hence, the mechanism underlying GX-evoked bone loss differs from that underlying OVX-evoked bone loss. The ability of alendronate, estrogen and PTH to reverse the GX-evoked osteopenia in the rat may be of clinical interest when dealing with bone loss in humans after GX.
Ämnesord och genrebeteckningar
-
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
-
MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
-
Alendronate
-
pharmacology
-
therapeutic use
-
Animals
-
Bone Density
-
drug effects
-
physiology
-
Bone Diseases
-
Metabolic
-
drug therapy
-
etiology
-
physiopathology
-
Diphosphonates
-
pharmacology
-
therapeutic use
-
Estrogens
-
pharmacology
-
therapeutic use
-
Female
-
Gastrectomy
-
adverse effects
-
Hormones
-
pharmacology
-
therapeutic use
-
Models
-
Animal
-
Ovariectomy
-
adverse effects
-
Parathyroid Hormone
-
pharmacology
-
therapeutic use
-
Rats
-
Rats
-
Sprague-Dawley
-
Tomography
-
X-Ray Computed
-
pharmacology
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Surve, VikasLund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Vascular Physiology,Lund University Research Groups(Swepub:lu)farm-vsu
(författare)
-
Lehto-Axtelius, Daisy
(författare)
-
Andersson, Kjell
(författare)
-
Ryberg, Birgitta
(författare)
-
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,University of Gothenburg(Swepub:gu)xohlcl
(författare)
-
Håkanson, RolfLund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)farm-rha
(författare)
-
Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för internmedicin
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Acta orthopaedica Scandinavica: Medical Journals Sweden AB75:2, s. 201-90001-64701651-1964
Internetlänk
Hitta via bibliotek
Till lärosätets databas