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Differential effect...
Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice.
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- Movérare, Sofia (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine,University of Gothenburg
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Venken, Katrien (författare)
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- Eriksson, Anna-Lena, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi,Institute of Internal Medicine, Dept of Clinical Pharmacology,University of Gothenburg
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- Andersson, Niklas, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,University of Gothenburg
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- Skrtic, Stanko, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi,Institute of Internal Medicine, Dept of Clinical Pharmacology,University of Gothenburg
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Wergedal, Jon (författare)
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Mohan, Subburaman (författare)
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Salmon, Phil (författare)
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Bouillon, Roger (författare)
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- Gustafsson, Jan-Ake (författare)
- Karolinska Institutet
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Vanderschueren, Dirk (författare)
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine,University of Gothenburg
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Wergedal, I (författare)
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(creator_code:org_t)
- 2003-10-22
- 2003
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 100:23, s. 13573-8
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Androgens may regulate the male skeleton either directly by stimulation of the androgen receptor (AR) or indirectly by aromatization of androgens into estrogens and, thereafter, by stimulation of the estrogen receptors (ERs). To directly compare the effect of ER activation on bone in vivo with the effect of AR activation, 9-month-old orchidectomized wild-type and ER-inactivated mice were treated with the nonaromatizable androgen 5alpha-dihydrotestosterone, 17beta-estradiol, or vehicle. Both ERalpha and AR but not ERbeta activation preserved the amount of trabecular bone. ERalpha activation resulted both in a preserved thickness and number of trabeculae. In contrast, AR activation exclusively preserved the number of trabeculae, whereas the thickness of the trabeculae was unaffected. Furthermore, the effects of 17beta-estradiol could not be mediated by the AR, and the effects of 5alpha-dihydrotestosterone were increased rather than decreased in ER-inactivated mice. ERalpha, but not AR or ERbeta, activation resulted in preserved thickness, volumetric density, and mechanical strength of the cortical bone. ERalpha activation increased serum levels of insulin-like growth factor I, which were positively correlated with all the cortical and trabecular bone parameters that were specifically preserved by ERalpha activation but not by AR activation, suggesting that insulin-like growth factor I might mediate these effects of ERalpha activation. Thus, the in vivo bone-sparing effect of ERalpha activation is distinct from the bone-sparing effect of AR activation in adult male mice. Because these two pathways are clearly distinct from each other, one may speculate that a combined treatment of selective ER modulators and selective AR modulators might be beneficial in the treatment of osteoporosis.
Nyckelord
- Animals
- Bone and Bones
- metabolism
- Dihydrotestosterone
- pharmacology
- Enzyme-Linked Immunosorbent Assay
- Estradiol
- pharmacology
- Estrogen Receptor alpha
- Female
- Heterozygote
- Insulin-Like Growth Factor I
- biosynthesis
- Male
- Mice
- Osteocalcin
- blood
- Osteoporosis
- metabolism
- Prostate
- metabolism
- Receptors
- Androgen
- physiology
- Receptors
- Estrogen
- physiology
- Time Factors
- Tomography
- X-Ray Computed
- Estradiol
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Movérare, Sofia
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Venken, Katrien
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Eriksson, Anna-L ...
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Andersson, Nikla ...
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Skrtic, Stanko, ...
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Wergedal, Jon
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Mohan, Subburama ...
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Salmon, Phil
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Bouillon, Roger
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Gustafsson, Jan- ...
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Vanderschueren, ...
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Ohlsson, Claes, ...
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Wergedal, I
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visa färre...
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Proceedings of t ...
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Proceedings of t ...
- Av lärosätet
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Göteborgs universitet
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Chalmers tekniska högskola
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Karolinska Institutet