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  • Lindberg, Marie K,1975Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine (author)

Two different pathways for the maintenance of trabecular bone in adult male mice.

  • Article/chapterEnglish2002

Publisher, publication year, extent ...

  • Wiley,2002

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/75353
  • https://gup.ub.gu.se/publication/75353URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1953113URI
  • https://doi.org/10.1359/jbmr.2002.17.4.555DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Androgens may regulate the male skeleton either directly via activation of the androgen receptor (AR) or indirectly via aromatization of androgens into estrogen and, thereafter, via activation of estrogen receptors (ERs). There are two known estrogen receptors, ER-alpha and ER-beta. The aim of this study was to investigate the relative roles of ER-alpha, ER-beta, and AR in the maintenance of trabecular bone in male mice. Seven-month-old male mice, lacking ER-alpha (ERKO), ER-beta (BERKO), or both receptors (DERKO), were orchidectomized (orx) and treated for 3 weeks with 0.7 microg/mouse per day of 17beta-estradiol or vehicle. No reduction in trabecular bone mineral density (BMD) was seen in ERKO, BERKO, or DERKO mice before orx, showing that neither ER-a nor ER-beta is required for the maintenance of a normal trabecular BMD in male mice. After orx, there was a pronounced decrease in trabecular BMD, similar for all groups, resulting in equal levels of trabecular BMD in all genotypes. This reduction was reversed completely in wild-type (WT) and BERKO mice treated with estrogen, and no significant effect of estrogen was found in ERKO or DERKO mice. In summary, the trabecular bone is preserved both by a testicular factor, presumably testosterone acting via AR and by an estrogen-induced activation of ER-alpha. These results indicate that AR and ER-alpha are redundant in the maintenance of the trabecular bone in male mice. In contrast, ER-beta is of no importance for the regulation of trabecular bone in male mice.

Subject headings and genre

  • Absorptiometry
  • Photon
  • Acid Phosphatase
  • blood
  • Animals
  • Bone Density
  • physiology
  • Estradiol
  • pharmacology
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Female
  • Femur
  • physiology
  • Insulin-Like Growth Factor I
  • metabolism
  • Isoenzymes
  • blood
  • Male
  • Mice
  • Mice
  • Mutant Strains
  • Mice
  • Transgenic
  • Orchiectomy
  • Receptors
  • Androgen
  • metabolism
  • Receptors
  • Estrogen
  • genetics
  • metabolism

Added entries (persons, corporate bodies, meetings, titles ...)

  • Movérare, SofiaGothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xmovso (author)
  • Skrtic, Stanko,1970Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi,Institute of Internal Medicine, Dept of Clinical Pharmacology(Swepub:gu)xskrst (author)
  • Alatalo, Sari L (author)
  • Halleen, Jussi M (author)
  • Mohan, Subburaman (author)
  • Gustafsson, J AKarolinska Institutet (author)
  • Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl (author)
  • Göteborgs universitetInstitutionen för invärtesmedicin (creator_code:org_t)

Related titles

  • In:Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research: Wiley17:4, s. 555-620884-0431

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