Interleukin-6-deficient mice develop mature-onset obesity.

• The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement. The obese Il6-/- mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)

Nyckelord

Age Factors

Animals

Blood Glucose

analysis

Body Composition

Corticosterone

blood

Eating

physiology

Energy Metabolism

physiology

Female

Glucose Tolerance Test

Injections

Intraventricular

Interleukin-6

deficiency

genetics

pharmacology

Leptin

blood

Lipids

blood

Male

Mice

Mice

Mutant Strains

Obesity

etiology

genetics

Sex Factors

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)