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  • Svensson, Johan,1964Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine (author)

Effects of growth hormone and its secretagogues on bone.

  • Article/chapterEnglish2001

Publisher, publication year, extent ...

  • 2001

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/75387
  • https://gup.ub.gu.se/publication/75387URI
  • https://doi.org/10.1385/ENDO:14:1:063DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The growth hormone (GH)/insulin-like growth factor-1 axis is not only of importance for linear body growth during childhood, but it is also one of the major determinants of adult bone mass. Studies show that GH treatment increases bone mass in rodents as well as in adult GH-deficient humans, but the effect of GH treatment on bone mass in healthy humans has so far not been impressive. Recently, a new class of GH secretagogues (GHSs) has been developed. In humans, GHS treatment affects biochemical markers of bone turnover and increases growth velocity in selected short children with or without GH deficiency. In rodents, GHS treatment increase bone mineral content, but it has not yet been shown that GHS treatment can affect bone mass in adult humans.

Subject headings and genre

  • Adult
  • Age Factors
  • Animals
  • Bone Development
  • drug effects
  • Bone Remodeling
  • drug effects
  • Bone Resorption
  • physiopathology
  • Bone and Bones
  • anatomy & histology
  • drug effects
  • Ghrelin
  • Growth Hormone
  • deficiency
  • pharmacology
  • Growth Hormone-Releasing Hormone
  • pharmacology
  • Hormones
  • pharmacology
  • Humans
  • Indoles
  • pharmacology
  • Oligopeptides
  • pharmacology
  • Organ Size
  • Peptide Hormones
  • Peptides
  • pharmacology
  • Spiro Compounds
  • pharmacology

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lall, S (author)
  • Dickson, Suzanne L.,1966Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xdicsu (author)
  • Bengtsson, Bengt-Åke,1944Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xbenbe (author)
  • Rømer, J (author)
  • Ahnfelt-Rønne, I (author)
  • Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl (author)
  • Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xjanjo (author)
  • Göteborgs universitetInstitutionen för invärtesmedicin (creator_code:org_t)

Related titles

  • In:Endocrine14:1, s. 63-60969-711X

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  • Endocrine (Search for host publication in LIBRIS)

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