Autoxidation of linalyl acetate, the main component of lavender oil, creates potent contact allergens

• Background: Fragrances are among the most common causes of allergic contact dermatitis. We have in previous studies shown that linalool, present in lavender oil, autoxidizes on air exposure, forming allergenic oxidation products. Oxidized linalool was found to be a frequent cause of contact allergy in a patch test study on consecutive dermatitis patients. Linalyl acetate, the main component of lavender oil is commonly used as a fragrance chemical in scented products. Because of structural similarities, linalyl acetate should also be susceptible to oxidation on air exposure, forming similar oxidation products as linalool.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

allergic contact dermatitis • autoxidation • fragrance • gas chromatographic analysis • hydroperoxide • linalool • linalyl acetate • local lymph node assay

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)