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  • Li, Lizhen,1977Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg (author)

Protective role of reactive astrocytes in brain ischemia.

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2007-08-29
  • SAGE Publications,2008

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/79142
  • https://gup.ub.gu.se/publication/79142URI
  • https://doi.org/10.1038/sj.jcbfm.9600546DOI
  • https://research.chalmers.se/publication/79142URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due to the absence of suitable experimental models. Previously, we generated mice deficient in two intermediate filament (IF) proteins, glial fibrillary acidic protein (GFAP) and vimentin, whose upregulation is the hallmark of reactive astrocytes. GFAP(-/-)Vim(-/-) mice exhibit attenuated posttraumatic reactive gliosis, improved integration of neural grafts, and posttraumatic regeneration. Seven days after middle cerebral artery (MCA) transection, infarct volume was 210 to 350% higher in GFAP(-/-)Vim(-/-) than in wild-type (WT) mice; GFAP(-/-), Vim(-/-) and WT mice had the same infarct volume. Endothelin B receptor (ET(B)R) immunoreactivity was strong on cultured astrocytes and reactive astrocytes around infarct in WT mice but undetectable in GFAP(-/-)Vim(-/-) astrocytes. In WT astrocytes, ET(B)R colocalized extensively with bundles of IFs. GFAP(-/-)Vim(-/-) astrocytes showed attenuated endothelin-3-induced blockage of gap junctions. Total and glutamate transporter-1 (GLT-1)-mediated glutamate transport was lower in GFAP(-/-)Vim(-/-) than in WT mice. DNA array analysis and quantitative real-time PCR showed downregulation of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of tissue plasminogen activator. Thus, reactive astrocytes have a protective role in brain ischemia, and the absence of astrocyte IFs is linked to changes in glutamate transport, ET(B)R-mediated control of gap junctions, and PAI-1 expression.

Subject headings and genre

  • Animals
  • Astrocytes
  • pathology
  • physiology
  • Brain Ischemia
  • metabolism
  • pathology
  • Gap Junctions
  • Glial Fibrillary Acidic Protein
  • deficiency
  • Glutamic Acid
  • metabolism
  • Mice
  • Mice
  • Knockout
  • Middle Cerebral Artery
  • Plasminogen Activator Inhibitor 1
  • genetics
  • Receptor
  • Endothelin B
  • analysis
  • Vimentin
  • deficiency
  • Glial Fibrillary Acidic Protein

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lundkvist, Andrea,1975Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg (author)
  • Andersson, Daniel,1979Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg(Swepub:gu)xadanw (author)
  • Wilhelmsson, Ulrika,1970Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg(Swepub:gu)xwilul (author)
  • Nagai, NobuoKatholieke Universiteit Leuven (author)
  • Pardo, Andrea CJohns Hopkins University (author)
  • Nodin, Christina,1974Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg(Swepub:gu)xnodcr (author)
  • Ståhlberg, Anders,1975Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)xsandw (author)
  • Aprico, KarinaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg (author)
  • Larsson, KerstinGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg (author)
  • Yabe, TakeshiNational Institute of Neurological Disorders and Stroke (author)
  • Moons, LieveKatholieke Universiteit Leuven (author)
  • Fotheringham, AndrewUniversity of Manchester (author)
  • Davies, IoanUniversity of Manchester (author)
  • Carmeliet, PeterKatholieke Universiteit Leuven (author)
  • Schwartz, Joan PNational Institute of Neurological Disorders and Stroke (author)
  • Pekna, Marcela,1966Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg(Swepub:gu)xpekma (author)
  • Kubista, Mikael,1961Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)mbtmk (author)
  • Blomstrand, Fredrik,1969Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg(Swepub:gu)xblofr (author)
  • Maragakis, NicholasJohns Hopkins University (author)
  • Nilsson, Michael,1962Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg(Swepub:gu)xnimic (author)
  • Pekny, Milos,1965Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg(Swepub:gu)xpekmi (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (creator_code:org_t)

Related titles

  • In:Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism: SAGE Publications28:3, s. 468-810271-678X1559-7016
  • In:Journal of Cerebral Blood Flow & Metabolism: SAGE Publications28:3, s. 468-811559-7016

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