Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF.

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Malmeström, Clas,1965Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation (author)

Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF.

Article/chapterEnglish2008

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Elsevier BV,2008

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LIBRIS-ID:oai:gup.ub.gu.se/79401
https://gup.ub.gu.se/publication/79401URI
https://doi.org/10.1016/j.jneuroim.2008.03.001DOI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

MS is thought to be mediated by CD4(+) T-helper cells. To investigate the importance of CD8(+) cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma and CSF levels of granzymes from MS patients and controls. Cytotoxic gene expression was decreased in peripheral T-cells from RRMS patients whereas plasma levels of granzymes were unchanged. However, granzyme levels were elevated in the CSF of RRMS patients at relapse compared with controls and remission. Thus, CD8+ T-cell-mediated cytotoxicity is confined to the CSF/CNS compartment in RRMS patients and may be involved in the immunopathogenesis of clinical relapses.

Subject headings and genre

Adult
Antigens
CD8
genetics
metabolism
Antigens
Differentiation
T-Lymphocyte
genetics
metabolism
CD8-Positive T-Lymphocytes
metabolism
Dipeptidyl Peptidase I
genetics
metabolism
Female
Flow Cytometry
methods
Gene Expression
Gene Expression Regulation
physiology
Granzymes
blood
cerebrospinal fluid
genetics
Humans
Male
Middle Aged
Multiple Sclerosis
Relapsing-Remitting
cerebrospinal fluid
pathology
Oligonucleotide Array Sequence Analysis
methods
Perforin
genetics
metabolism
RNA
Messenger
metabolism

Added entries (persons, corporate bodies, meetings, titles ...)

Lycke, Jan,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xlycja (author)
Haghighi, SaraGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xhagsa (author)
Andersen, Oluf,1941Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xandeo (author)
Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcarle (author)
Wadenvik, Hans,1955Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xwadha (author)
Olsson, Bob,1969Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xolsbo (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (creator_code:org_t)

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In:Journal of neuroimmunology: Elsevier BV196:1-2, s. 159-650165-5728

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