The peptidergic innervation of the rat parotid gland: effects of section of the auriculo-temporal nerve and/or of otic ganglionectomy.

Khosravani, NinaGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Odontology,Institute of Neuroscience and Physiology, Department of Pharmacology (author)

The origin/pathways of peptidergic nerves contributing to the parotid gland contents of vasoactive intestinal peptide (VIP), substance P and calcitonin gene-related peptide (CGRP) were investigated by performing surgery on one side of the rat. Comparisons (based on total amount of peptide) were made between the gland on the operated side and the contralateral gland 7 days postoperatively. Otic ganglionectomy showed that almost all of the parotid gland contents of VIP (98%) and substance P (98%) were due to the otic connection, while this was true for only a minor portion (32%) of the CGRP-gland content. Section of the auriculo-temporal nerve showed that almost all of the VIP- and substance P-containing nerve fibres reached the parotid gland via this nerve, as judged by a reduction in the VIP-content by 88% and in the substance P-content by 93%, while the CGRP-content was only reduced by 37%. Section of the auriculo-temporal nerve combined with otic ganglionectomy did not reduce the gland contents of CGRP and substance P further than just otic ganglionectomy. Thus, the auriculo-temporal nerve is not likely to innervate the parotid gland with CGRP- and/or substance P-containing nerve fibres from the trigeminal ganglion.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
Animals
Biological Markers
analysis
Calcitonin Gene-Related Peptide
analysis
Cranial Nerves
surgery
Female
Ganglionectomy
Nerve Fibers
chemistry
Neuropeptides
analysis
Parotid Gland
chemistry
innervation
Radioimmunoassay
methods
Rats
Rats
Sprague-Dawley
Substance P
analysis
Vasoactive Intestinal Peptide
analysis

Ekman, Rolf,1938 (author)
Ekström, Jörgen,1944Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xeksjo (author)
Göteborgs universitetInstitutionen för odontologi (creator_code:org_t)

By the author/editor: Khosravani, Nina; Ekman, Rolf, 193 ...; Ekström, Jörgen, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

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