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Gender differences ...
Gender differences in heritability of depressive symptoms in the elderly
- Artikel/kapitelEngelska2004
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LIBRIS-ID:oai:gup.ub.gu.se/81587
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https://gup.ub.gu.se/publication/81587URI
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https://doi.org/10.1017/S0033291703001375DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1946894URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-2603URI
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: The present study aimed to investigate the relative importance of genetic and environmental influences on depressive symptoms in the elderly. METHOD: Depressive symptoms were assessed through the Center for Epidemiological Studies-Depression (CES-D) scale. The CES-D scale was administered to 959 twin pairs (123 female MZs, 90 male MZs, 207 same-sex female DZs, 109 same-sex male DZs and 430 opposite-sex DZs) aged 50 years or older (mean age 72 years). A dichotomous depressed state variable was constructed based on CES-D cut-offs and self-reported use of antidepressant medication. Structural equation models were fitted to the data to dissect genetic and environmental variance components. RESULTS: The sex-specific heritability estimates for depressive symptoms were 14% for males and 29% for females and 23% when constrained to be equal for men and women. The prevalence of clinically significant depressive symptoms was 16% for men and 24% for women. Heritability estimates for the dichotomous depressed state measure were 7% for males and 49% for females in the full model and 33% when constrained to be equal. CONCLUSION: Our results suggest that depressive symptoms in the elderly are moderately heritable, with a higher heritability for women than men, although differences in heritability estimates were not statistically significant.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gatz, M.
(författare)
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Berg, S.Jönköping University,HHJ, Institutet för gerontologi,HHJ. Åldrande - livsvillkor och hälsa
(författare)
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Johansson, BooGothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology(Swepub:gu)xjoboo
(författare)
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Malmberg, BoJönköping University,HHJ, Institutet för gerontologi,HHJ. Åldrande - livsvillkor och hälsa(Swepub:hj)Malb
(författare)
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McClearn, G.E.
(författare)
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Schalling, M.Karolinska Institutet
(författare)
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Pedersen, Nancy L.Karolinska Institutet
(författare)
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Jönköping UniversityHHJ, Institutet för gerontologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:PSYCHOLOGICAL MEDICINE34:3, s. 471-4790033-29171469-8978
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