Fox's in development and disease.

• Since the first forkhead (Fox) gene was identified, the importance of this family of transcription factors has increased steadily with the discoveries of the diverse range of developmental processes that they regulate in eukaryotes. Among other processes, the Fox factors are important in the establishment of the body axis and the development of tissues from all three germ layers. In this article, we present some of the recent data on this gene family with reference to selected phenotypes observed in patients and model organisms, and the sensitivity of developmental processes to alterations in forkhead gene dosage.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

Animals

Anterior Eye Segment

abnormalities

pathology

Cornea

abnormalities

pathology

DNA-Binding Proteins

genetics

physiology

Eye Abnormalities

genetics

pathology

Forkhead Transcription Factors

Humans

Iris

abnormalities

pathology

Mice

Mutation

Transcription Factors

genetics

physiology

Publikations- och innehållstyp

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