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Anti-HSV-1 and anti...
Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate.
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Müller Kratz, Jadel (author)
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- Andrighetti-Fröhner, Carla Regina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Kolling, Deise Juliana (author)
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Leal, Paulo César (author)
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Cirne-Santos, Cláudio César (author)
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Yunes, Rosendo Augusto (author)
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Nunes, Ricardo José (author)
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- Trybala, Edward, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Frugulhetti, Izabel C P P (author)
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Barardi Monte, Célia Regina (author)
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Oliveira Simões, Cláudia Maria (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Memórias do Instituto Oswaldo Cruz. - 1678-8060. ; 103:5, s. 437-42
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Animals
- Anti-HIV Agents
- pharmacology
- Antiviral Agents
- pharmacology
- Cattle
- Cercopithecus aethiops
- Gallic Acid
- analogs & derivatives
- pharmacology
- HIV-1
- drug effects
- Herpesvirus 1
- Human
- drug effects
- Humans
- Leukocytes
- Mononuclear
- drug effects
- Vero Cells
- Virus Replication
- drug effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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Müller Kratz, Ja ...
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Andrighetti-Fröh ...
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Kolling, Deise J ...
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Leal, Paulo Césa ...
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Cirne-Santos, Cl ...
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Yunes, Rosendo A ...
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Nunes, Ricardo J ...
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Trybala, Edward, ...
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Bergström, Tomas ...
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Frugulhetti, Iza ...
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Barardi Monte, C ...
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Oliveira Simões, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Microbiology in ...
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Memórias do Inst ...
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University of Gothenburg