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  • Adamovic, Svetlana,1965Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg (author)

Fine mapping study in Scandinavian families suggests association between coeliac disease and haplotypes in chromosome region 5q32.

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2007-10-30
  • Wiley,2008

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/82767
  • https://gup.ub.gu.se/publication/82767URI
  • https://doi.org/10.1111/j.1399-0039.2007.00955.xDOI
  • https://research.chalmers.se/publication/82767URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The previous genome-wide scan in Scandinavian families supported earlier evidence for linkage of a region on chromosome 5 (5q31–33) to coeliac disease. This study deals with further genetic mapping of an 18 cM region, spanning from marker GAh18A (131.87 Mb) to D5S640 (149.96 Mb). Linkage and association analyses were performed in a two-step approach. First, seven microsatellites were added. Strong evidence for linkage was obtained with a Zlr score of 3.96, Pnc = 4 × 10−5 at marker D5S436. The strongest association was with a haplotype consisting of the markers D5S2033 and D5S2490 (Pnc < 0.001). In the second step, we added 17 microsatellites and 69 single nucleotide polymorphisms (SNPs) to the analysis. These markers were located close to or within candidate genes across the region of approximately 7 Mb beneath the linkage peak marked by D5S2017 and D5S812. A substantial increase of the linkage signal with a maximum Zlr score of 4.6 at marker rs1972644 (Pnc = 2 × 10−6) was obtained and several SNPs showed association. Seven SNPs that individually showed the strongest association were genotyped in a second independent family sample set (225 trios). In the trio family sample as well as in the multiplex family sample, the strongest association was found with SNPs within the region flanked by the associated microsatellites D5S2033 and D5S2490 at 5q32.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Amundsen, S. S.Universitetet i Oslo,University of Oslo (author)
  • Lie, Benedicte AlexandraUniversitetet i Oslo,University of Oslo (author)
  • Hellqvist, ÅsaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg(Swepub:gu)xhelas (author)
  • Gudjonsdottir, Audur,1959Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg(Swepub:gu)xgudau (author)
  • Ek, Johan (author)
  • Nilsson, Staffan,1956Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg(Swepub:cth)staffan (author)
  • Wahlström, Jan,1939Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg(Swepub:gu)xwahja (author)
  • Ascher, Henry,1953Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Nordiska Hogskolan for folkhalsovetenskap(Swepub:gu)xasche (author)
  • Sollid, Ludvig MUniversitetet i Oslo,University of Oslo (author)
  • Torinsson Naluai, Åsa,1968Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg(Swepub:gu)xnalas (author)
  • Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik (creator_code:org_t)

Related titles

  • In:Tissue Antigens: Wiley71:1, s. 27-341399-00390001-2815

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