Surgical treatment of epilepsy--clinical, radiological and histopathological findings in 139 children and adults.

• The present study relates clinical and radiological data to histopathological diagnoses in the first 139 patients (children and adults) in the G?teborg Epilepsy Surgery series. Temporal lobe resections were most common (54.0%) followed by frontal lobe (18.0%) and multilobar resections (11.5%). All histopathological specimens were re-evaluated in connection with this study. Parenchymal malformations and atrophic-gliotic lesions were the most common histopathological findings. Microdysgenesis was more common than major malformations (24.5% versus 11.5%). When the MRI scans were blindly re-evaluated the MRI findings correlated with histopathological diagnosis in all of the vascular malformations, in 77.8% of the tumours, in 76.5% of the cases with hippocampal sclerosis but only in 28.6% of the major cortical development malformations. Hemispherectomies carried the best seizure outcome prognosis followed by temporal lobe resections (75.0% versus 57.3% seizure free 2 years after surgery). Vascular malformations carried the best, and microdysgenesis the worst prognosis (76.9% versus 39.4% seizure free).

Keyword

Adolescent

Adult

Child

Corpus Callosum

surgery

Epilepsy

pathology

radiography

surgery

Female

Frontal Lobe

pathology

surgery

Humans

Intracranial Arteriovenous Malformations

pathology

Magnetic Resonance Imaging

Male

Middle Aged

Prognosis

Retrospective Studies

Seizures

Temporal Lobe

pathology

surgery

Treatment Outcome

Publication and Content Type

ref (subject category)

art (subject category)