The extracellular matrix of the spleen as a potential organizer of immune cell compartments.

• Until recently little information was available on the molecular details of the extracellular matrix (ECM) of secondary lymphoid tissues. There is now growing evidence that these ECMs are unique structures, combining characteristics of basement membranes and interstitial or fibrillar matrices, resulting in scaffolds that are strong and highly flexible and, in certain secondary lymphoid compartments, also forming conduit networks for rapid fluid transport. This review will address the structural characteristics of the ECM of the murine spleen and its potential role as an organizer of immune cell compartments, with reference to the lymph node where relevant.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Animals

Antigens

Differentiation

B-Lymphocyte Subsets

cytology

immunology

Basement Membrane

immunology

metabolism

Biological Transport

immunology

Chemokines

immunology

Endothelial Cells

cytology

immunology

metabolism

Extracellular Matrix

immunology

Extracellular Matrix Proteins

immunology

metabolism

Humans

Immunity

Cellular

Immunohistochemistry

Mice

Rats

Spleen

cytology

immunology

Publication and Content Type

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