Mouse chromosome 19 and distal rat chromosome 1: a chromosome segment conserved in evolution.

• Through a combination of radiation hybrid mapping and studies by FISH and zoo-FISH we have made a comparative investigation of the distal portion of rat chromosome 1 (RNO1) and the entire mouse chromosome 19 (MMU19). It was found that homologous segments of RNO1 and MMU19 are similar in banding morphology and in length as determined by several different methods, and that the gene order of the 46 genes studied appears to be conserved across the homologous segments in the two species. High-resolution zoo-FISH techniques showed that MMU19 probes highlight only a continuous segment on RNO1 (1q43-qter), with no detectable signals on other rat chromosomes. We conclude that these data suggest the evolutionary conservation of a chromosomal segment from a common rodent ancestor. This segment now constitutes the entire MMU19 and a large segment distally on RNO1q in the mouse and rat, respectively.

Subject headings

NATURVETENSKAP  -- Biologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Keyword

Animals

Cells

Cultured

Chromosome Mapping

Chromosomes

genetics

ultrastructure

Evolution

Molecular

In Situ Hybridization

Fluorescence

Mice

genetics

Phylogeny

Quantitative Trait

Heritable

Radiation Hybrid Mapping

Rats

genetics

Rodentia

classification

genetics

Species Specificity

Publication and Content Type

ref (subject category)

art (subject category)