The local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10.

• Helicobacter pylori causes a life-long infection that may lead to development of gastric adenocarcinoma (GC) and thereby cause major worldwide health problems. The present study was designed to study whether those that develop GC have an altered immune response to H. pylori compared to individuals that remain asymptomatic. When stimulated with H. pylori antigens, T cells from both peripheral blood and gastric mucosa of H. pylori-infected GC patients produced high amounts of IL-10, while the IL-10 production from blood T cells of H. pylori-infected asymptomatic subjects was low. Furthermore, mRNA levels of IL-10 were increased in the gastric mucosa of GC patients. In addition, the frequency of activated CD8(+) T cells was markedly reduced in stomach mucosa of patients with GC compared to asymptomatic individuals. We propose that the increased production of the suppressive cytokine IL-10 in H. pylori-infected GC patients leads to a diminished cytotoxic anti-tumour T-cell response in the stomach, which may contribute to tumour progression in subjects suffering from GC.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Adenocarcinoma

immunology

microbiology

Adult

Aged

Aged

80 and over

Cell Proliferation

Female

Flow Cytometry

Gastric Mucosa

immunology

microbiology

Helicobacter Infections

blood

immunology

microbiology

Helicobacter pylori

immunology

Humans

Interferon-gamma

immunology

Interleukin-10

biosynthesis

genetics

immunology

Male

Middle Aged

RNA

Messenger

chemistry

genetics

Reverse Transcriptase Polymerase Chain Reaction

Statistics

Nonparametric

Stomach Neoplasms

immunology

microbiology

T-Lymphocytes

immunology

microbiology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)