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Long-term effects o...
Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus.
- Article/chapterEnglish2008
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LIBRIS-ID:oai:gup.ub.gu.se/85149
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https://gup.ub.gu.se/publication/85149URI
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https://doi.org/10.1016/j.jacc.2008.09.049DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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OBJECTIVES: The aim of this substudy was to ascertain whether long-term treatment with fenofibrate reduces surrogate measures of atherosclerosis, biomarkers of inflammation, and endothelial activation in patients with type 2 diabetes. BACKGROUND: Some fibrates may decrease cardiovascular events, improve endothelial function, and reduce levels of acute-phase proteins. In the FIELD (Fenofibrate Intervention and Event Lowering in Diabetes) study, fenofibrate failed to decrease the primary end point of coronary events in patients with type 2 diabetes. METHODS: A total of 170 patients with type 2 diabetes of the FIELD Helsinki cohort were randomly assigned to micronized fenofibrate 200 mg/day or placebo in a double-blind design. Carotid intima-media thickness (IMT) and the augmentation index (a measure of large artery stiffness) were measured at baseline and at second- and fifth-year visits. Plasma levels of interleukin (IL)-6, C-reactive protein (CRP), serum amyloid A (SAA), secretory phospholipase A2 IIA (SPLA2), E-selectin, vascular cellular adhesion molecule (VCAM)-1, and intercellular adhesion molecule (CAM)-1 were determined by commercial enzyme-linked immunosorbent assay kits at the same visits. RESULTS: IMT and the augmentation index increased similarly in both treatment groups during the study. Plasma levels of CRP, IL-6, SPLA2, SAA, VCAM-1, ICAM-1, and E-selectin remained unchanged in both groups. CONCLUSIONS: Fenofibrate treatment was not associated with beneficial changes in IMT, augmentation index, or biomarkers of inflammation and endothelial function. (Fenofibrate Intervention and Event Lowering in Diabetes; NCT00132886).
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Westerbacka, Jukka
(author)
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Leinonen, Eeva S
(author)
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Watanabe, Hiroshi
(author)
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Wiklund, Olov,1943Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xwikol
(author)
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Mattsson Hultén, Lillemor,1951Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xmatli
(author)
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Salonen, Jukka T
(author)
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Tuomainen, Tomi-Pekka
(author)
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Yki-Järvinen, Hannele
(author)
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Keech, Anthony C
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Taskinen, Marja-Riitta
(author)
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Göteborgs universitetWallenberglaboratoriet
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In:Journal of the American College of Cardiology: Elsevier BV52:25, s. 2190-71558-35970735-1097
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