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Red cell distributi...
Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank
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Felker, G. M. (author)
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Allen, L. A. (author)
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Pocock, S. J. (author)
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show more...
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Shaw, L. K. (author)
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McMurray, J. J. (author)
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Pfeffer, M. A. (author)
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- Swedberg, Karl, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine
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Wang, D. (author)
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Yusuf, S. (author)
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Michelson, E. L. (author)
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Granger, C. B. (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: J Am Coll Cardiol. - 1558-3597. ; 50:1, s. 40-7
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- OBJECTIVES: The goal of this study was to identify potentially novel laboratory markers of risk in chronic heart failure patients. BACKGROUND: Although a variety of prognostic markers have been described in heart failure, a systematic assessment of routine laboratory values has not been reported. METHODS: All 2,679 symptomatic chronic heart failure patients from the North American CHARM (Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity) program had a wide range of laboratory measures performed at a core facility, enabling us to assess the relationship between routine blood tests and outcomes using a Cox proportional hazards model. We then replicated our findings in a cohort of 2,140 heart failure patients from the Duke Databank. RESULTS: Among 36 laboratory values considered in the CHARM program, higher red cell distribution width (RDW) showed the greatest association with morbidity and mortality (adjusted hazard ratio 1.17 per 1-SD increase, p < 0.001). Higher RDW was among the most powerful overall predictors, with only age and cardiomegaly showing a better independent association with outcome. This finding was replicated in the Duke Databank, in which higher RDW was strongly associated with all-cause mortality (adjusted hazard ratio 1.29 per 1 SD, p < 0.001), second only to age as a predictor of outcome. CONCLUSIONS: In 2 large contemporary heart failure populations, RDW was found to be a very strong independent predictor of morbidity and mortality. Understanding how and why this marker is associated with outcome may provide novel insights into heart failure pathophysiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Aged
- Benzimidazoles/*therapeutic use
- Biological Markers/blood
- *Cause of Death
- Cohort Studies
- Databases as Topic
- Disease Progression
- Erythrocytes/*cytology
- Female
- Heart Failure/diagnosis/*drug therapy/*mortality
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Probability
- Prognosis
- Proportional Hazards Models
- Randomized Controlled Trials as Topic
- Risk Assessment
- Sensitivity and Specificity
- Severity of Illness Index
- Survival Analysis
- Tetrazoles/*therapeutic use
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Felker, G. M.
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Allen, L. A.
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Pocock, S. J.
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Shaw, L. K.
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McMurray, J. J.
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Pfeffer, M. A.
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show more...
-
Swedberg, Karl, ...
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Wang, D.
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Yusuf, S.
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Michelson, E. L.
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Granger, C. B.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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J Am Coll Cardio ...
- By the university
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University of Gothenburg