Proteomics of Neuropathic Pain: Proteins and Signaling Pathways Affected in a Rat Model

Sui, PingUppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab (författare)

Proteomics of Neuropathic Pain : Proteins and Signaling Pathways Affected in a Rat Model

The myriad proteins may be involved in the mechanisms underlying the development and maintenance of neuropathic pain, an extremely disabling condition that originates from pathology of the nervous system. To address the mechanisms, we here analyzed proteins and cellular networks in the dorsal spinal cord mediating pain processing in a well-established rat model of neuropathic pain induced by spinal nerve ligation (SNL). Labeling-based proteomic methods together with high-resolution mass spectrometry for proteome analysis were applied. 38 proteins including synapsin 1 and microtubule-associated protein 2 were identified as differently expressed in the SNL group. Pathway analysis suggests that maladaptive changes in the levels of these proteins may contribute to abnormal synaptic transmission and neuronal intracellular signaling underlying the onset and development of neuropathic pain.

Watanabe, HiroyukiUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)hirwa520 (författare)
Ossipov, Michael (författare)
Bakalkin, GeorgyUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)gueba200 (författare)
Artemenko, KonstantinUppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab(Swepub:uu)konar476 (författare)
Bergquist, JonasUppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab(Swepub:uu)jbe25356 (författare)
Uppsala universitetAnalytisk kemi (creator_code:org_t)

Ingår i:Journal of Proteome Research: American Chemical Society (ACS)13:9, s. 3957-39651535-38931535-3907

Av författaren/redakt...: Sui, Ping; Watanabe, Hiroyu ...; Ossipov, Michael; Bakalkin, Georgy; Artemenko, Konst ...; Bergquist, Jonas

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