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Nitric oxide (NO) i...
Nitric oxide (NO) in exhaled air after experimental ozone exposure in humans.
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- Olin, Anna-Carin, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Stenfors, Nikolai (författare)
- Umeå universitet,Lungmedicin,Department for Respiratory Medicine and Allergy, University Hospital and Medical Division, National Institute for Working Life, Umeå
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- Torén, Kjell, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Blomberg, Anders, 1961- (författare)
- Umeå universitet,Lungmedicin,Department for Respiratory Medicine and Allergy, University Hospital and Medical Division, National Institute for Working Life, Umeå
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- Helleday, Ragnberth (författare)
- Umeå universitet,Lungmedicin,Department for Respiratory Medicine and Allergy, University Hospital and Medical Division, National Institute for Working Life, Umeå
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Ledin, M C (författare)
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- Ljungkvist, G (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Ekman, Anna, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Sandström, Thomas, 1957- (författare)
- Umeå universitet,Lungmedicin,Department for Respiratory Medicine and Allergy, University Hospital and Medical Division, National Institute for Working Life, Umeå
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(creator_code:org_t)
- Elsevier BV, 2001
- 2001
- Engelska.
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Ingår i: Respiratory medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 95:6, s. 491-5
- Relaterad länk:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- We hypothesized that ozone, a common air pollutant, potent in producing airway inflammation, would increase the production of exhaled nitric oxide (NO). If so, measurement of exhaled NO could potentially be a valuable tool in population studies of air pollution effects. Eleven healthy non-smoking volunteers were exposed to 0.2 ppm ozone (O3) and filtered air for 2h on two separate occasions. Exhaled NO and nasal NO were measured before and on five occasions following the exposures. Changes in exhaled and nasal NO after ozone exposure were adjusted for changes after air exposure. There was a slight decrease in exhaled NO (-0.6; -3.1-1.2 ppb) (median and 95% confidence interval) and of nasal NO (-57; -173-75 ppb) directly after the ozone exposure. No significant changes in exhaled or nasal NO were however found 6 or 24 h after the exposure. Within the examined group, an O3 exposure level proven to induce an airway inflammation caused no significant changes in exhaled or nasal NO levels. Hence, the current study did not yield support for exhaled NO as a useful marker of ozone-induced oxidative stress and airway inflammation after a single exposure. This contrasts with data for workers exposed to repeated high peaks of ozone. The potential for exhaled NO as a marker of oxidative stress therefore deserves to be further elucidated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Adult
- Biological Markers
- Breath Tests
- Chemiluminescent Measurements
- Confidence Intervals
- Environmental Exposure
- Female
- Humans
- Leukocyte Count
- Male
- Neutrophils
- Nitric Oxide
- analysis
- metabolism
- Oxidative Stress
- physiology
- Ozone
- administration & dosage
- metabolism
- Peroxidase
- blood
- Predictive Value of Tests
- nitric oxide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Olin, Anna-Carin ...
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Stenfors, Nikola ...
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Torén, Kjell, 19 ...
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Blomberg, Anders ...
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Helleday, Ragnbe ...
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Ledin, M C
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Ljungkvist, G
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Ekman, Anna, 196 ...
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Sandström, Thoma ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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Respiratory medi ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet