Disproportional body growth in female estrogen receptor-alpha-inactivated mice.

• Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of ERalpha in the regulation of body growth and skeletal growth. Adult female mice with inactivated ERalpha (ERalpha-/-) demonstrated an increased body weight compared with wild-type mice (114% of control). However, the length of the appendicular skeleton was decreased in adult ERalpha-/- mice (femur 93% of control). In contrast, the axial skeleton was normal (crown-rump length 98% of control). The decreased growth of the appendicular skeleton was associated with decreased serum levels of IGF-I (77% of control), indicating that the GH/IGF-I axis may be involved in the decreased longitudinal bone growth seen in female ERalpha-/- mice.

Nyckelord

Animals

Base Sequence

Body Weight

genetics

physiology

Bone Development

genetics

physiology

DNA Primers

genetics

Estrogen Receptor alpha

Female

Growth

genetics

physiology

Growth Plate

growth & development

Humans

Insulin-Like Growth Factor I

metabolism

Mice

Mice

Inbred C57BL

Mice

Knockout

Organ Size

genetics

physiology

Phenotype

Receptors

Estrogen

genetics

physiology

Species Specificity

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)