Disproportional body growth in female estrogen receptor-alpha-inactivated mice.

Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of ERalpha in the regulation of body growth and skeletal growth. Adult female mice with inactivated ERalpha (ERalpha-/-) demonstrated an increased body weight compared with wild-type mice (114% of control). However, the length of the appendicular skeleton was decreased in adult ERalpha-/- mice (femur 93% of control). In contrast, the axial skeleton was normal (crown-rump length 98% of control). The decreased growth of the appendicular skeleton was associated with decreased serum levels of IGF-I (77% of control), indicating that the GH/IGF-I axis may be involved in the decreased longitudinal bone growth seen in female ERalpha-/- mice.

Lindberg, Marie K,1975Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine (författare)
Sävendahl, LarsKarolinska Institutet (författare)
Lubahn, D B (författare)
Ritzen, E MKarolinska Institutet (författare)
Gustafsson, J AKarolinska Institutet (författare)
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl (författare)
Göteborgs universitetInstitutionen för invärtesmedicin (creator_code:org_t)

Ingår i:Biochemical and biophysical research communications: Elsevier BV265:2, s. 569-710006-291X

Av författaren/redakt...: Vidal, Olle; Lindberg, Marie ...; Sävendahl, Lars; Lubahn, D B; Ritzen, E M; Gustafsson, J A; visa fler...; Ohlsson, Claes, ...; visa färre...

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