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Treatment with the ...
Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males.
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- Svensson, Johan, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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Murphy, G (author)
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Wyss, D (author)
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Krupa, D (author)
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Cerchio, K (author)
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Polvino, W (author)
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Gertz, B (author)
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Baylink, D J (author)
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Mohan, Subburaman (author)
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- Bengtsson, Bengt-Åke, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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(creator_code:org_t)
- 1998
- 1998
- English.
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In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - 0884-0431. ; 13:7, s. 1158-66
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- The effect of 2 months of treatment with the oral growth hormone (GH) secretagogue MK-677 on markers of bone metabolism was determined in healthy obese male subjects. This was a randomized, double-blind, parallel, placebo-controlled study. Twenty-four healthy obese males, 19-49 years of age, with body mass index > 30 kg/m2 were treated with MK-677 (25 mg/day; n = 12) or placebo (n = 12) for 8 weeks. MK-677 increased markers of bone formation; a 23% increase in the carboxy-terminal propeptide of type I procollagen levels and a 28% increase in procollagen III peptide levels were seen with as little as 2 weeks of MK-677 treatment (p < 0.01 and p = 0.001 vs. placebo, respectively) while a 15% increase in serum levels of osteocalcin was not detected until 8 weeks of treatment (p < 0.01 vs. placebo). Markers of bone resorption were induced within 2 weeks of treatment with MK-677; serum levels of the carboxy-terminal cross-linked telopeptide of type I collagen were increased 26% at 8 weeks (p = 0.001 vs. placebo), and urine hydroxyproline/creatinine and calcium/creatinine ratios at 8 weeks were increased by 23% (p < 0.05 vs. placebo) and 46% (p < 0.05 vs placebo), respectively, MK-677 increased serum insulin-like growth factor binding protein-5 (IGFBP-5) by 43-44% after 2-8 weeks of treatment (p < 0.01 vs. placebo). Serum IGFBP-4 was increased by 25% after 2 weeks of treatment (p < 0.001 vs. placebo) but no significant change from baseline was observed after 8 weeks of treatment. Plasma interleukin-6 was not significantly changed by active treatment. In conclusion, short-term treatment of healthy obese male volunteers with the GH secretagogue MK-677 increases markers of both bone resorption and formation. Large increases in serum levels of IGF-1 and IGFBP-5 and a transient increase in serum IGFBP-4 were found. Future long-term studies are needed to investigate if prolonged treatment with MK-677 increases bone mass.
Keyword
- Administration
- Oral
- Adult
- Biological Markers
- blood
- Bone Density
- drug effects
- Bone Remodeling
- drug effects
- Collagen
- blood
- Collagen Type I
- Double-Blind Method
- Humans
- Indoles
- administration & dosage
- therapeutic use
- Insulin-Like Growth Factor Binding Protein 4
- blood
- Insulin-Like Growth Factor Binding Protein 5
- blood
- Interleukins
- blood
- Male
- Middle Aged
- Obesity
- blood
- drug therapy
- Osteocalcin
- blood
- Peptide Fragments
- blood
- Peptides
- blood
- Procollagen
- blood
- Spiro Compounds
- administration & dosage
- therapeutic use
Publication and Content Type
- ref (subject category)
- art (subject category)
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Svensson, Johan, ...
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Ohlsson, Claes, ...
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Jansson, John-Ol ...
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Murphy, G
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Wyss, D
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Krupa, D
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show more...
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Cerchio, K
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Polvino, W
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Gertz, B
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Baylink, D J
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Mohan, Subburama ...
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Bengtsson, Bengt ...
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Journal of bone ...
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University of Gothenburg