Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration.

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Fibrinogen Studies, Collaboration (author)

Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration.

Article/chapterEnglish2007

Publisher, publication year, extent ...

2007-08-28
Oxford University Press (OUP),2007

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/91546
https://gup.ub.gu.se/publication/91546URI
https://doi.org/10.1093/aje/kwm191DOI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Long-term increases in plasma fibrinogen levels of 1 g/liter are associated with an approximate doubling of risk of major cardiovascular disease outcomes, but causality remains uncertain. To quantify cross-sectional associations of fibrinogen levels with established risk factors and other characteristics, the investigators combined individual data on 154,211 apparently healthy adults from 31 prospective studies conducted between 1967 and 2003, using a linear mixed model that included random effects at the cohort level. Fibrinogen levels increased with age and showed continuous, approximately linear relations with several risk markers and slightly curvilinear associations with log triglycerides, albumin, and tobacco and alcohol consumption. Female sex, Black ethnicity, lower socioeconomic status, and alcohol abstinence were each associated with modestly higher fibrinogen levels. Approximately one third of the variation in fibrinogen levels was explained by cohort, age, and sex. An additional 7% was explained by established risk factors (notably, positive associations with smoking and body mass index and an inverse association with high density lipoprotein cholesterol), and a further 10% was explained by inflammatory markers (notably, a positive association with C-reactive protein). The association with body mass index was twice as strong in women as in men, whereas the association with smoking was much stronger in men. These findings substantially advance understanding of the correlates and possible determinants of fibrinogen levels.

Subject headings and genre

Adult
African Americans
statistics & numerical data
Age Factors
Biological Markers
blood
Body Mass Index
C-Reactive Protein
metabolism
Cardiovascular Diseases
blood
epidemiology
Cohort Studies
Female
Fibrinogen
metabolism
Humans
Linear Models
Male
Prospective Studies
Risk Factors
Sex Factors
Smoking
adverse effects
Social Class
United States
epidemiology

Added entries (persons, corporate bodies, meetings, titles ...)

Kaptoge, S (author)
White, I R (author)
Thompson, S G (author)
Wood, A M (author)
Lewington, S (author)
Lowe, G D O (author)
Danesh, J (author)
Wilhelmsen, Lars,1932Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine(Swepub:gu)xwilhl (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för akut och kardiovaskulär medicin (creator_code:org_t)

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In:American journal of epidemiology: Oxford University Press (OUP)166:8, s. 867-790002-92621476-6256

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