Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.

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Brittberg, Mats,1953Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi,Institute of Surgical Sciences, Department of Orthopaedics (författare)

Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.

Artikel/kapitelEngelska1994

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1994

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LIBRIS-ID:oai:gup.ub.gu.se/91635
https://gup.ub.gu.se/publication/91635URI

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Språk:engelska

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Ämneskategori:art swepub-publicationtype

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BACKGROUND. Full-thickness defects of articular cartilage in the knee have a poor capacity for repair. They may progress to osteoarthritis and require total knee replacement. We performed autologous chondrocyte transplantation in 23 people with deep cartilage defects in the knee. METHODS. The patients ranged in age from 14 to 48 years and had full-thickness cartilage defects that ranged in size from 1.6 to 6.5 cm2. Healthy chondrocytes obtained from an uninvolved area of the injured knee during arthroscopy were isolated and cultured in the laboratory for 14 to 21 days. The cultured chondrocytes were then injected into the area of the defect. The defect was covered with a sutured periosteal flap taken from the proximal medial tibia. Evaluation included clinical examination according to explicit criteria and arthroscopic examination with a biopsy of the transplantation site. RESULTS. Patients were followed for 16 to 66 months (mean, 39). Initially, the transplants eliminated knee locking and reduced pain and swelling in all patients. After three months, arthroscopy showed that the transplants were level with the surrounding tissue and spongy when probed, with visible borders. A second arthroscopic examination showed that in many instances the transplants had the same macroscopic appearance as they had earlier but were firmer when probed and similar in appearance to the surrounding cartilage. Two years after transplantation, 14 of the 16 patients with femoral condylar transplants had good-to-excellent results. Two patients required a second operation because of severe central wear in the transplants, with locking and pain. A mean of 36 months after transplantation, the results were excellent or good in two of the seven patients with patellar transplants, fair in three, and poor in two; two patients required a second operation because of severe chondromalacia. Biopsies showed that 11 of the 15 femoral transplants and 1 of the 7 patellar transplants had the appearance of hyaline cartilage. CONCLUSION. Cultured autologous chondrocytes can be used to repair deep cartilage defects in the femorotibial articular surface of the knee joint.

Ämnesord och genrebeteckningar

Adolescent
Adult
Cartilage
Articular
cytology
surgery
Cell Transplantation
methods
Cells
Cultured
Female
Humans
Joint Diseases
surgery
Knee Joint
surgery
Male
Middle Aged
Patella
surgery
Reoperation
Surgical Flaps
Transplantation
Autologous

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lindahl, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xlandy (författare)
Nilsson, Anders,1958Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi,Institute of Surgical Sciences, Department of Orthopaedics(Swepub:gu)xniand (författare)
Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl (författare)
Isaksson, Olle,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xisaol (författare)
Peterson, Lars,1936Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi,Institute of Surgical Sciences, Department of Orthopaedics(Swepub:gu)xpelar (författare)
Göteborgs universitetInstitutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi (creator_code:org_t)

Sammanhörande titlar

Ingår i:The New England journal of medicine331:14, s. 889-950028-4793

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Av författaren/redakt...: Brittberg, Mats, ...; Lindahl, Anders, ...; Nilsson, Anders, ...; Ohlsson, Claes, ...; Isaksson, Olle, ...; Peterson, Lars, ...

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