Sökning: WFRF:(Dahlström Annica 1941) >
Neuroendocrine secr...
Neuroendocrine secretory protein 55 (NESP55) in the spinal cord of rat: an immunocytochemical study.
-
- Li, Yongling, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
-
Fischer-Colbrie, Reiner (författare)
-
- Dahlström, Annica, 1941 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
-
(creator_code:org_t)
- 2007
- 2008
- Engelska.
-
Ingår i: The Journal of comparative neurology. - : Wiley. - 0021-9967 .- 1096-9861. ; 506:4, s. 733-44
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The immunohistochemical expression of a novel chromogranin-like protein, neuroendocrine secretory protein 55 (NESP55), in the rat spinal cord was investigated. NESP55-immunoreactive cells were detected in the ventral horn, intermediate laminae, and deep dorsal horn, comprising motoneurons, autonomic neurons, and interneurons throughout all spinal segments. Within laminae I-II of the dorsal horn, one or two NESP55-positive cells were often seen. Nerve fibers also contained NESP55 immunoreactivity (IR) and were particularly prominent in the ventral horn. No nerve terminals/varicosities appeared to contain NESP55 in any spinal lamina. Double-staining experiments revealed that a high proportion of the NESP55-positive neurons were cholinergic. Moreover, NESP55-IR in the motoneurons was evenly distributed in the whole cytoplasm with a finely granular appearance. In contrast, the fluorescent material in the preganglionic neurons was concentrated in the perinuclear region and largely overlapped with the trans-Golgi network marker TGN38. Our data provide detailed morphological information on the distribution of NESP55-IR in the rat spinal cord. Also, the differential intracellular expression of NESP55-IR in the spinal motoneurons and autonomic neurons suggests that NESP55 may be processed into different secretory granules and may be involved in both constitutive and regulated pathways in these neurons.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Acetylcholine
- metabolism
- Animals
- Autonomic Nervous System
- cytology
- metabolism
- Axons
- metabolism
- ultrastructure
- Cytoplasm
- metabolism
- ultrastructure
- Female
- GTP-Binding Protein alpha Subunits
- Gs
- metabolism
- Immunohistochemistry
- Interneurons
- cytology
- metabolism
- Male
- Membrane Glycoproteins
- metabolism
- Motor Neurons
- cytology
- metabolism
- Neurons
- cytology
- metabolism
- Neurosecretion
- physiology
- Rats
- Rats
- Sprague-Dawley
- Secretory Vesicles
- metabolism
- ultrastructure
- Spinal Cord
- cytology
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas