The cellular composition and morphological organization of the rostral migratory stream in the adult human brain.

The rostral migratory stream (RMS) is the major pathway by which progenitor cells migrate from the subventricular zone (SVZ) to the olfactory bulb (OB) in rodents, rabbits and primates. However, the existence of an RMS within the adult human brain has been elusive. Immunohistochemical studies utilising cell-type specific markers for early progenitor cells (CD133), proliferating cells (PCNA), astrocytes and type B cells (GFAP) and migrating neuroblasts (PSA-NCAM), reveal that the adult human RMS is organized into layers containing glial cells, proliferating cells and neuroblasts. In addition, the RMS is arranged around a remnant of the ventricular cavity that extends from the SVZ to the OB as seen by immunohistological staining analysis and electron microscopy, showing the presence of basal bodies and a typical 9+2 arrangement of tubulin in tufts of cilia from all levels of the RMS. Overall, these findings suggest that a pathway of migratory progenitor cells similar to that seen in other mammals is present within the adult human brain and that this pathway could provide for neurogenesis in the human forebrain. These findings contribute to the scientific understanding of adult neurogenesis and establish the detailed cytoarchitecture of this novel neurogenic niche in the human brain.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Adult
Animals
Antigens
CD
metabolism
Brain
anatomy & histology
cytology
Cell Movement
physiology
Cerebral Ventricles
cytology
physiology
Cilia
physiology
Coloring Agents
Eosine Yellowish-(YS)
Fluorescent Dyes
Glial Fibrillary Acidic Protein
metabolism
Glycoproteins
metabolism
Hematoxylin
Humans
Image Processing
Computer-Assisted
Immunohistochemistry
Indoles
Male
Microscopy
Electron
Transmission
Neural Cell Adhesion Molecules
metabolism
Neural Pathways
anatomy & histology
cytology
metabolism
Olfactory Bulb
cytology
physiology
Paraffin Embedding
Peptides
metabolism
Proliferating Cell Nuclear Antigen
metabolism
Rats

Curtis, Maurice AGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xcurma (författare)
McGlashan, Susan R (författare)
Connor, Bronwen (författare)
Nannmark, Ulf,1958Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xnanul (författare)
Faull, Richard L M (författare)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (creator_code:org_t)

Ingår i:Journal of chemical neuroanatomy: Elsevier BV37:3, s. 196-2051873-63000891-0618

Av författaren/redakt...: Kam, Monica; Curtis, Maurice ...; McGlashan, Susan ...; Connor, Bronwen; Nannmark, Ulf, 1 ...; Faull, Richard L ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Fysiologi

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