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The cellular compos...
The cellular composition and morphological organization of the rostral migratory stream in the adult human brain.
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Kam, Monica (författare)
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- Curtis, Maurice A (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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McGlashan, Susan R (författare)
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Connor, Bronwen (författare)
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- Nannmark, Ulf, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Faull, Richard L M (författare)
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Journal of chemical neuroanatomy. - : Elsevier BV. - 1873-6300 .- 0891-0618. ; 37:3, s. 196-205
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The rostral migratory stream (RMS) is the major pathway by which progenitor cells migrate from the subventricular zone (SVZ) to the olfactory bulb (OB) in rodents, rabbits and primates. However, the existence of an RMS within the adult human brain has been elusive. Immunohistochemical studies utilising cell-type specific markers for early progenitor cells (CD133), proliferating cells (PCNA), astrocytes and type B cells (GFAP) and migrating neuroblasts (PSA-NCAM), reveal that the adult human RMS is organized into layers containing glial cells, proliferating cells and neuroblasts. In addition, the RMS is arranged around a remnant of the ventricular cavity that extends from the SVZ to the OB as seen by immunohistological staining analysis and electron microscopy, showing the presence of basal bodies and a typical 9+2 arrangement of tubulin in tufts of cilia from all levels of the RMS. Overall, these findings suggest that a pathway of migratory progenitor cells similar to that seen in other mammals is present within the adult human brain and that this pathway could provide for neurogenesis in the human forebrain. These findings contribute to the scientific understanding of adult neurogenesis and establish the detailed cytoarchitecture of this novel neurogenic niche in the human brain.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Adult
- Animals
- Antigens
- CD
- metabolism
- Brain
- anatomy & histology
- cytology
- Cell Movement
- physiology
- Cerebral Ventricles
- cytology
- physiology
- Cilia
- physiology
- Coloring Agents
- Eosine Yellowish-(YS)
- Fluorescent Dyes
- Glial Fibrillary Acidic Protein
- metabolism
- Glycoproteins
- metabolism
- Hematoxylin
- Humans
- Image Processing
- Computer-Assisted
- Immunohistochemistry
- Indoles
- Male
- Microscopy
- Electron
- Transmission
- Neural Cell Adhesion Molecules
- metabolism
- Neural Pathways
- anatomy & histology
- cytology
- metabolism
- Olfactory Bulb
- cytology
- physiology
- Paraffin Embedding
- Peptides
- metabolism
- Proliferating Cell Nuclear Antigen
- metabolism
- Rats
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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