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WFRF:(Jürgen D.)
 

Search: WFRF:(Jürgen D.) > (2005-2009) > Prolactin prevents ...

Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate.

Torner, Luz (author)
Karg, Sandra (author)
Blume, Annegret (author)
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Kandasamy, Mahesh (author)
Kuhn, Hans-Georg, 1961 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Winkler, Jürgen (author)
Aigner, Ludwig (author)
Neumann, Inga D (author)
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 (creator_code:org_t)
2009
2009
English.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience. - 1529-2401. ; 29:6, s. 1826-33
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Chronic exposure to stress results in a reduction of hippocampal neurogenesis and of hippocampal volume. We examined whether prolactin (PRL), a regulator of the stress response and stimulator of neurogenesis in the subventricular zone, influences neurogenesis in the hippocampal dentate gyrus (DG) of chronically stressed adult C57BL/6 male mice. Chronically stressed (4 h daily immobilization for 21 d) or nonstressed mice were treated with either ovine PRL or vehicle between days 1-14. BrdU was injected daily between days 1-7 to evaluate cell survival and fate, or twice on day 21 to evaluate cell proliferation. Hippocampal cell proliferation was unchanged by either stress exposure or PRL at the end of the treatments. In contrast, the number of cells in the DG that incorporated BrdU during the first phase of the experiment and survived to the end of the experiment was decreased in vehicle-treated stressed mice compared with PRL- or vehicle-treated nonstressed control mice. Stressed animals receiving PRL had significantly more BrdU-labeled cells than vehicle-treated stressed mice at this time point. Cell fate analysis revealed a higher percentage of neurons in PRL- compared with vehicle-treated stressed mice. The results demonstrate that PRL protects neurogenesis in the DG of chronically stressed mice and promotes neuronal fate.

Keyword

Animals
Cell Differentiation
physiology
Cell Proliferation
Chronic Disease
Dentate Gyrus
cytology
physiology
Growth Inhibitors
physiology
Male
Mice
Mice
Inbred C57BL
Neurogenesis
physiology
Neurons
cytology
Prolactin
physiology
therapeutic use
Sheep
Stress
Psychological
metabolism
pathology
prevention & control

Publication and Content Type

ref (subject category)
art (subject category)

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